MK 6096

ChemicalBook > CAS DataBase List > MK 6096

Product Name: MK 6096
CAS No.: 1088991-73-4
Chemical Name: MK 6096
Synonyms: MK6096;MK-6096;CS-1825;MK 6096;Filorexant;MK 6096;MK6096;MK-6096(Filorexant);Filorexant(MK-6096);filorexant / MK-6096, CID25128145;Inhibitor,inhibit,MK 6096,Orexin Receptor (OX Receptor),MK6096,Filorexant,Hypocretin Receptor,HCRT Receptor
CBNumber: CB32666757
Molecular Formula: C24H25FN4O2
Formula Weight: 420.48
MOL File: 1088991-73-4.mol

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MK 6096 Property

Boiling point:: 540.2±50.0 °C(Predicted)
Density: 1.203±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 2mg/mL; Ethanol: 5mg/mL
form: A solid
pka: 1.54±0.22(Predicted)
color: Off-white to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29490
Product name: Filorexant
Packaging: 25mg
Price: $421
Updated: 2024/03/01

Cayman Chemical

Product number: 29490
Product name: Filorexant
Packaging: 50mg
Price: $629
Updated: 2024/03/01

Cayman Chemical

Product number: 29490
Product name: Filorexant
Packaging: 5mg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 29490
Product name: Filorexant
Packaging: 10mg
Price: $253
Updated: 2024/03/01

TRC

Product number: F337008
Product name: Filorexant
Packaging: 5mg
Price: $140
Updated: 2021/12/16

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MK 6096 Chemical Properties,Usage,Production

Description

Filorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (K_is = 2.5 and 0.31 nM, respectively, for the recombinant human receptors). It selectively inhibits OX1R and OX2R over a panel of more than 170 receptors and enzymes. Filorexant inhibits orexin A-induced calcium mobilization in CHO cells expressing recombinant human OX1R or OX2R (K_b = 11 nM for both). It decreases locomotor activity in rats during the dark cycle when administered at a dose of 10 mg/kg. Filorexant (0.5 mg/kg) reduces the time spent awake and decreases the latency to slow-wave sleep stage 1 (SWS1) and SWS2, but not rapid eye movement (REM) sleep, in dogs. It increases the duration of SWS2, but not SWS1 or REM sleep, in the same model.

Uses

Filorexant is a selective dual orexin receptor antagonist with potent sleep-promoting properties. It has advanced into phase II clinical trials for the treatment of insomnia.

MK 6096 Preparation Products And Raw materials

Raw materials

Preparation Products

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1088991-73-4, MK 6096Related Search:

Filorexant

MK 6096

MK6096

MK-6096

MK 6096;MK6096

CS-1825

MK-6096(Filorexant)

((2R,5R)-5-(((5-Fluoropyridin-2-yl)oxy)methyl)-2-methylpiperidin-1-yl)(5-methyl-2-(pyrimidin-2-yl)phenyl)methanone MK6096

[(2R,5R)-5-[[(5-Fluoro-2-pyridinyl)oxy]methyl]-2-methyl-1-piperidinyl][5-methyl-2-(2-pyrimidinyl)phenyl]methanone

Filorexant(MK-6096)

[(2R,5R)-5-[(5-FLUOROPYRIDIN-2-YL)OXYMETHYL]-2-METHYLPIPERIDIN-1-YL]-(5-METHYL-2-PYRIMIDIN-2-YLPHENYL)METHANONE

filorexant / MK-6096, CID25128145

Methanone, [(2R,5R)-5-[[(5-fluoro-2-pyridinyl)oxy]methyl]-2-methyl-1-piperidinyl][5-methyl-2-(2-pyrimidinyl)phenyl]-

Inhibitor,inhibit,MK 6096,Orexin Receptor (OX Receptor),MK6096,Filorexant,Hypocretin Receptor,HCRT Receptor

1088991-73-4