AMG 511

Product Name: AMG 511
CAS No.: 1253573-53-3
Chemical Name: AMG 511
Synonyms: AMG 511;AMG 511 (AMG-511;AMG 511, 10 mM in DMSO;AMG511,AMG-511,Inhibitor,PI3K,PI3Kβ,AMG 511,malignant,PI3Kγ,PI3Kα,Phosphoinositide 3-kinase,inhibit,glioblastoma,PI3Kδ,glioma;4-{2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methanesulfonylpiperazin-1-yl)ethyl]pyridin-3-yl}-6-methyl-1,3,5-triazin-2-amine;(R)-4-(2-((5-Fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4-[2-[(5-fluoro-6-methoxy-3-pyridinyl)amino]-5-[(1R)-1-[4-(methylsulfonyl)-1-piperazinyl]ethyl]-3-pyridinyl]-6-methyl-
CBNumber: CB32666818
Molecular Formula: C22H28FN9O3S
Formula Weight: 517.58
MOL File: 1253573-53-3.mol

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AMG 511 Property

solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A576580
Product name: AMG-511
Packaging: 5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0006892
Product name: AMG511
Purity: 98.81%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0006892
Product name: AMG511
Purity: 98.81%
Packaging: 10mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-0006892
Product name: AMG511
Purity: 98.81%
Packaging: 25mg
Price: $940
Updated: 2021/12/16

AK Scientific

Product number: SYN5398
Product name: AMG-511
Packaging: 100mg
Price: $2680
Updated: 2021/12/16

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AMG 511 Chemical Properties,Usage,Production

Uses

AMG-511 is a PI3Kα inhibitor used as a cancer therapeutic due to its effect on cell growth and cell survival.

in vivo

AMG 511 potently blocks the targeted PI3K pathway in a mouse liver pharmacodynamic model (3-30 mg/kg; p.o.) and inhibits tumor growth in a U87 MG glioblastoma xenograft model (3-30 mg/kg; p.o.; daily; for 12 days)^[1].
AMG 511 shows excellent in vivo efficacy and pharmacokinetic profile^[1].

Animal Model:	Female CD1 NU/NU mice, with U87 MG glioblastoma xenograft model^[1]
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	Oral administration, daily, for 12 days
Result:	Inhibited tumor growth.

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	1 mg/kg
Administration:	Oral administration (Pharmacokinetic Analysis)
Result:	Had a superior pharmacokinetic profile with low clearance (0.4 L/h/kg, 12% of liver blood flow), good oral bioavailability (F = 60%), and a commensurate high oral exposure (AUC = 5.0 μM·h).

IC 50

PI3Kα: 4 nM (Ki); PI3Kβ: 6 nM (Ki); PI3Kδ: 2 nM (Ki); PI3Kγ: 1 nM (Ki)

References

[1] MARK H. NORMAN*. Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511[J]. Journal of Medicinal Chemistry, 2012, 55 17: 7796-7816. DOI: 10.1021/jm300846z

AMG 511 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG 511 Suppliers

Canada 1 China 21 United States 6 Global 28

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777;
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
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Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
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Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4796
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
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Email: sales@chemegen.com
Country: China
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Energy Chemical

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Fax: 021-58436166
Email: marketing1@energy-chemical.com
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ProdList: 44893
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1253573-53-3, AMG 511Related Search:

AMG 511

AMG 511 (AMG-511

1,3,5-Triazin-2-amine, 4-[2-[(5-fluoro-6-methoxy-3-pyridinyl)amino]-5-[(1R)-1-[4-(methylsulfonyl)-1-piperazinyl]ethyl]-3-pyridinyl]-6-methyl-

(R)-4-(2-((5-Fluoro-6-methoxypyridin-3-yl)amino)-5-(1-(4-(methylsulfonyl)piperazin-1-yl)ethyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

AMG511,AMG-511,Inhibitor,PI3K,PI3Kβ,AMG 511,malignant,PI3Kγ,PI3Kα,Phosphoinositide 3-kinase,inhibit,glioblastoma,PI3Kδ,glioma

4-{2-[(5-fluoro-6-methoxypyridin-3-yl)amino]-5-[(1R)-1-(4-methanesulfonylpiperazin-1-yl)ethyl]pyridin-3-yl}-6-methyl-1,3,5-triazin-2-amine

AMG 511, 10 mM in DMSO

1253573-53-3

253573-53-3

C22H28FN9O3S