ChemicalBook > CAS DataBase List > Auristatin E

Auristatin E

Product Name
Auristatin E
CAS No.
160800-57-7
Chemical Name
Auristatin E
Synonyms
Auristatin E;Auristatin E,inhibit,ADC Payload,ADC Cytotoxin,Inhibitor,Microtubule/Tubulin;L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-;(2S)-2-[(2S)-2-(dimethylamino)-3-methylbutanamido]-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide;(S)-2-((S)-2-(Dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide
CBNumber
CB32667365
Molecular Formula
C40H69N5O7
Formula Weight
732.01
MOL File
160800-57-7.mol
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Auristatin E Property

Melting point:
92-94 °C
Boiling point:
871.0±65.0 °C(Predicted)
Density 
1.085±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C,unstable in solution, ready to use.
solubility 
Soluble in DMSO
form 
Solid
pka
13.66±0.20(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H341Suspected of causing genetic defects

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3435
Product name
AuristatinE
Purity
99.36%
Packaging
1mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-3435
Product name
AuristatinE
Purity
99.36%
Packaging
5mg
Price
$440
Updated
2021/12/16
ChemScene
Product number
CS-3435
Product name
AuristatinE
Purity
99.36%
Packaging
10mg
Price
$740
Updated
2021/12/16
BroadPharm
Product number
BP-23645
Product name
AuristatinE
Purity
95%
Packaging
50mg
Price
$1300
Updated
2021/12/16
DC Chemicals
Product number
DC10138
Product name
AuristatinE
Purity
>98%
Packaging
100mg
Price
$950
Updated
2021/12/16
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Auristatin E Chemical Properties,Usage,Production

Description

Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; it is a synthetic analog of dolastatin 10. Auristatin E is a highly potent antimitotic agent. Auristatin E inhibits tubulin polymerization(1). Auristatin E-antibody cunjugates have proven to be successful anticancer agents.(2)
Ref. 1. Pettit et al. Anticancer Drug Des. 1995 10:529.
Ref. 2. Doronina et al. Nature Biotechnol. 2003 21:778.

Auristatin E Preparation Products And Raw materials

Raw materials

Preparation Products

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Auristatin E Suppliers

China 68 United States 10 Global 78
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View Lastest Price from Auristatin E manufacturers

Hangzhou Huarong Pharm Co., Ltd.
Product
Auristatin E 160800-57-7
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2021-09-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
Auristatin E 160800-57-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Auristatin E 160800-57-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

160800-57-7, Auristatin ERelated Search:

Auristatin F Ozone Feed Mould inhibitor

  • Auristatin E
  • L-Valinamide, N,N-dimethyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-
  • Auristatin E,inhibit,ADC Payload,ADC Cytotoxin,Inhibitor,Microtubule/Tubulin
  • (S)-2-((S)-2-(Dimethylamino)-3-methylbutanamido)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)-N,3-dimethylbutanamide
  • (2S)-2-[(2S)-2-(dimethylamino)-3-methylbutanamido]-N-[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
  • 160800-57-7
  • 160800-57-8
  • C40H69N5O7