S1RA

ChemicalBook > CAS DataBase List > S1RA

Product Name: S1RA
CAS No.: 878141-96-9
Chemical Name: S1RA
Synonyms: S1RA;E52862;CS-1020;S1RA, >=98%;S1RA(E-52862);S1RA, 878141-96-9;E-52862; E52862; E 52862;4-(2-{[5-Methyl-1-(2-naphthyl)-1H-pyrazol-3-yl]oxy}ethyl)morpholi ne;4-(2-{[5-Methyl-1-(naphthalen-2-yl)pyrazol-3-yl]oxy}ethyl)morpholine;4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine
CBNumber: CB32667552
Molecular Formula: C20H23N3O2
Formula Weight: 337.42
MOL File: 878141-96-9.mol

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S1RA Property

Boiling point:: 528.1±50.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥10.35 mg/mL in DMSO; ≥12.23 mg/mL in EtOH; ≥56.1 mg/mL in H2O
form: solid
pka: 6.15±0.10(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16279
Product name: S1RA
Purity: ≥98%
Packaging: 500μg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 16279
Product name: S1RA
Purity: ≥98%
Packaging: 1mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 16279
Product name: S1RA
Purity: ≥98%
Packaging: 5mg
Price: $435
Updated: 2024/03/01

Cayman Chemical

Product number: 16279
Product name: S1RA
Purity: ≥98%
Packaging: 10mg
Price: $711
Updated: 2024/03/01

Biorbyt Ltd

Product number: orb181123
Product name: S1RA
Purity: >98%
Packaging: 100mg
Price: $765
Updated: 2021/12/16

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S1RA Chemical Properties,Usage,Production

Biological Activity

s1ra is a potent and selective antagonist of σ1 receptor (σ1r) with ki value of 17nm [1].s1ra is the first σ1 receptor antagonist with potent antinociceptive activities in various pain models. in the binding assay, s1ra shows good affinity to human σ1 receptor transfected in hek293 membranes with ki value of 17nm. the ki value for guinea pig brain membrane σ1 receptor is higher than 1μm. s1ra also shows no significant affinity to another 170 molecular targets including receptors, ion channels and enzymes [1, 2].in the mouse tests, s1ra exhibits potent analgesic effects on capsaicin-induced mechanical hypersensitivity and formalin-induced pain. besides that, s1ra inhibits both mechanical allodynia and thermal hypersensitivity with ed50 values of 23.4mg/kg and 18.8mg/kg in the partial sciatic nerve ligation model in mice [1].

References

[1] díaz j l, cuberes r, berrocal j, et al. synthesis and biological evaluation of the 1-arylpyrazole class of σ1 receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1 h-pyrazol-3-yloxy] ethyl} morpholine (s1ra, e-52862). journal of medicinal chemistry, 2012, 55(19): 8211-8224.
[2] wunsch b. the σ1 receptor antagonist s1ra is a promising candidate for the treatment of neurogenic painj. journal of medicinal chemistry, 2012, 55(19): 8209-8210.

S1RA Preparation Products And Raw materials

Raw materials

Preparation Products

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878141-96-9, S1RARelated Search:

S1RA

4-(2-(5-METHYL-1-(NAPHTHALEN-2-YL)-1H-PYRAZOL-3-YLOXY)ETHYL)MORPHOLINE. HCL

4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine

4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine S1RA

S1RA 4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine

S1RA, >=98%

S1RA, 878141-96-9

4-(2-((5-Methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yl)oxy)ethyl)morpholine

E52862

S1RA(E-52862)

4-(2-{[5-Methyl-1-(2-naphthyl)-1H-pyrazol-3-yl]oxy}ethyl)morpholi ne

CS-1020

E-52862; E52862; E 52862

Morpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-

4-(2-{[5-Methyl-1-(naphthalen-2-yl)pyrazol-3-yl]oxy}ethyl)morpholine

878141-96-9

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