ChemicalBook > CAS DataBase List > Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-
Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-
- Product Name
- Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-
- CAS No.
- 1111636-35-1
- Chemical Name
- Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-
- Synonyms
- CS-727;PF-04880594;PF-04880594/PF04880594;3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile;Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile DISCONTINUED
- CBNumber
- CB32667567
- Molecular Formula
- C19H16F2N8
- Formula Weight
- 394.38
- MOL File
- 1111636-35-1.mol
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Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- Soluble in DMSO
- form
- powder
- pka
- 12.99±0.40(Predicted)
- color
- white to beige
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PZ0294
- Product name
- PF-04880594
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $115
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- PZ0294
- Product name
- PF-04880594
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $361
- Updated
- 2023/06/20
Medical Isotopes, Inc.
- Product number
- 57031
- Product name
- 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-β]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile
- Packaging
- 5mg
- Price
- $775
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 57031
- Product name
- 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-β]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile
- Packaging
- 50mg
- Price
- $3200
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC8727
- Product name
- PF-04880594
- Purity
- >98%
- Packaging
- 250mg
- Price
- $800
- Updated
- 2021/12/16
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Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Chemical Properties,Usage,Production
Uses
3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile is a pyrazole compound and a potential Raf inhibitors.
Biochem/physiol Actions
PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models.
target
BRAFV599E
Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Preparation Products And Raw materials
Raw materials
Preparation Products
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Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Suppliers
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