Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-

Product Name: Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-
CAS No.: 1111636-35-1
Chemical Name: Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-
Synonyms: CS-727;PF-04880594;PF-04880594/PF04880594;3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile;Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-;3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile DISCONTINUED
CBNumber: CB32667567
Molecular Formula: C19H16F2N8
Formula Weight: 394.38
MOL File: 1111636-35-1.mol

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Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: Soluble in DMSO
form: powder
pka: 12.99±0.40(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0294
Product name: PF-04880594
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $115
Updated: 2023/06/20

Sigma-Aldrich

Product number: PZ0294
Product name: PF-04880594
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $361
Updated: 2023/06/20

Medical Isotopes, Inc.

Product number: 57031
Product name: 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-β]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile
Packaging: 5mg
Price: $775
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 57031
Product name: 3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-β]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile
Packaging: 50mg
Price: $3200
Updated: 2021/12/16

DC Chemicals

Product number: DC8727
Product name: PF-04880594
Purity: >98%
Packaging: 250mg
Price: $800
Updated: 2021/12/16

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Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Chemical Properties,Usage,Production

Uses

3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile is a pyrazole compound and a potential Raf inhibitors.

Biochem/physiol Actions

PF-04880594 is a potent and selective RAF inhibitor that inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 potently inhibits tumor growth in BRAF-mutant melanoma xenograft models.

target

BRAFV599E

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]- Suppliers

Canada 1 China 26 United States 4 Global 31

Shanghai Boyle Chemical Co., Ltd.

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Sigma-Aldrich

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Hangzhou Synstar pharmaceutical Technology CO.,Ltd

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DC Chemicals

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Changzhou Chenhong Biotechnology Co., Ltd.

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1111636-35-1, Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-Related Search:

3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazol-4-yl]pyrimidin-2-yl]amino]propanenitrile

PF-04880594/PF04880594

Propanenitrile, 3-[[4-[1-(2,2-difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyriMidinyl]aMino]-

PF-04880594

3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile

CS-727

3-[[4-[1-(2,2-Difluoroethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazol-4-yl]-2-pyrimidinyl]amino]propanenitrile DISCONTINUED

1111636-35-1

C19H16F2N8