Debio 0932 ,CUDC-305

Product Name: Debio 0932 ,CUDC-305
CAS No.: 1061318-81-7
Chemical Name: Debio 0932 ,CUDC-305
Synonyms: CS-1423;bio 0932;CUDC-305;Debio 0932;Debio 0932 ,CUDC-305;CUDC-305 (DEBIO-0932 );1H-Imidazo[4,5-c]pyridine-1-ethanamine, 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-
CBNumber: CB32667714
Molecular Formula: C22H30N6O2S
Formula Weight: 442.58
MOL File: 1061318-81-7.mol

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Debio 0932 ,CUDC-305 Property

Boiling point:: 654.8±65.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:33.0(Max Conc. mg/mL);74.56(Max Conc. mM)
form: A crystalline solid
pka: 10.02±0.19(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 24683
Product name: CUDC-305
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 24683
Product name: CUDC-305
Purity: ≥98%
Packaging: 5mg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 24683
Product name: CUDC-305
Purity: ≥98%
Packaging: 10mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 24683
Product name: CUDC-305
Purity: ≥98%
Packaging: 25mg
Price: $684
Updated: 2024/03/01

ChemScene

Product number: CS-5630
Product name: Debio0932
Purity: 99.97%
Packaging: 5mg
Price: $132
Updated: 2021/12/16

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Debio 0932 ,CUDC-305 Chemical Properties,Usage,Production

Uses

Debio 0932 (CUDC-305) is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively[1].

in vivo

Debio 0932 (CUDC-305, 30 mg/kg, p.o.) exhibits favorable pharmacokinetic profiles in tumor-bearing nude mice. Debio 0932 (160 mg/kg, p.o.) causes degradation of HSP90 client proteins, suppresses tumor growth, and also prolongs survival in various animal models of U87MG glioblastoma. Debio 0932 (40, 80, or 160 mg/kg, p.o.) also dose-dependently inhibits tumor growth in the U87MG s.c. tumor model by every-other-day (q2d) dosing^[1]. Debio 0932 (80 mg/kg, p.o.) significantly alleviates psoriasis by day 11 and decreases epidermal thickness in psoriasis xenograft transplantation model^[2]. Debio 0932 (CUDC-305) is able to cross the blood-brain barrier. Debio 0932 (80, 120, and 160 mg/kg, p.o.) shows dose-dependent inhibition of tumor growth in the H1975 subcutaneous tumor model. Debio 0932 (160 mg/kg, p.o.) also promotes antitumor activity in the erlotinib-resistant H1975 subcutaneous tumor model^[3].

IC 50

HSP90α: 100 nM (IC₅₀); HSP90β: 103 nM (IC₅₀)

References

[1] Bao R, et al. CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy. Clin Cancer Res. 2009 Jun 15;15(12):4046-57. DOI:10.1158/1078-0432.CCR-09-0152
[2] Stenderup K, et al. Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model. Acta Derm Venereol. 2014 Nov;94(6):672-6. DOI:10.2340/00015555-1838
[3] Bao R, et al. Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer. Mol Cancer Ther. 2009 Dec;8(12):3296-306. DOI:10.1158/1535-7163.MCT-09-0538

Debio 0932 ,CUDC-305 Preparation Products And Raw materials

Raw materials

Preparation Products

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Debio 0932 ,CUDC-305 Suppliers

China 52 United States 8 Global 60

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View Lastest Price from Debio 0932 ,CUDC-305 manufacturers

Career Henan Chemical Co

Product: Debio 0932 ,CUDC-305 1061318-81-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-23

1061318-81-7, Debio 0932 ,CUDC-305Related Search:

Debio 0932

Debio 0932 ,CUDC-305

CUDC-305 (DEBIO-0932 )

CUDC-305

CS-1423

1H-Imidazo[4,5-c]pyridine-1-ethanamine, 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-

bio 0932

1061318-81-7