Debio 0932 ,CUDC-305
- Product Name
- Debio 0932 ,CUDC-305
- CAS No.
- 1061318-81-7
- Chemical Name
- Debio 0932 ,CUDC-305
- Synonyms
- CS-1423;bio 0932;CUDC-305;Debio 0932;Debio 0932 ,CUDC-305;CUDC-305 (DEBIO-0932 );1H-Imidazo[4,5-c]pyridine-1-ethanamine, 4-amino-2-[[6-(dimethylamino)-1,3-benzodioxol-5-yl]thio]-N-(2,2-dimethylpropyl)-
- CBNumber
- CB32667714
- Molecular Formula
- C22H30N6O2S
- Formula Weight
- 442.58
- MOL File
- 1061318-81-7.mol
Debio 0932 ,CUDC-305 Property
- Boiling point:
- 654.8±65.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:33.0(Max Conc. mg/mL);74.56(Max Conc. mM)
- form
- A crystalline solid
- pka
- 10.02±0.19(Predicted)
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 24683
- Product name
- CUDC-305
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 24683
- Product name
- CUDC-305
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 24683
- Product name
- CUDC-305
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $302
- Updated
- 2024/03/01
- Product number
- 24683
- Product name
- CUDC-305
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $684
- Updated
- 2024/03/01
- Product number
- CS-5630
- Product name
- Debio0932
- Purity
- 99.97%
- Packaging
- 100mg
- Price
- $1020
- Updated
- 2021/12/16
Debio 0932 ,CUDC-305 Chemical Properties,Usage,Production
Uses
Debio 0932 (CUDC-305) is an orally active HSP90 inhibitor, with IC50s of 100 and 103 nM for HSP90α and HSP90β, respectively[1].
in vivo
Debio 0932 (CUDC-305, 30 mg/kg, p.o.) exhibits favorable pharmacokinetic profiles in tumor-bearing nude mice. Debio 0932 (160 mg/kg, p.o.) causes degradation of HSP90 client proteins, suppresses tumor growth, and also prolongs survival in various animal models of U87MG glioblastoma. Debio 0932 (40, 80, or 160 mg/kg, p.o.) also dose-dependently inhibits tumor growth in the U87MG s.c. tumor model by every-other-day (q2d) dosing[1]. Debio 0932 (80 mg/kg, p.o.) significantly alleviates psoriasis by day 11 and decreases epidermal thickness in psoriasis xenograft transplantation model[2]. Debio 0932 (CUDC-305) is able to cross the blood-brain barrier. Debio 0932 (80, 120, and 160 mg/kg, p.o.) shows dose-dependent inhibition of tumor growth in the H1975 subcutaneous tumor model. Debio 0932 (160 mg/kg, p.o.) also promotes antitumor activity in the erlotinib-resistant H1975 subcutaneous tumor model[3].
IC 50
HSP90α: 100 nM (IC50); HSP90β: 103 nM (IC50)
References
[1] Bao R, et al. CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy. Clin Cancer Res. 2009 Jun 15;15(12):4046-57. DOI:10.1158/1078-0432.CCR-09-0152
[2] Stenderup K, et al. Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model. Acta Derm Venereol. 2014 Nov;94(6):672-6. DOI:10.2340/00015555-1838
[3] Bao R, et al. Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer. Mol Cancer Ther. 2009 Dec;8(12):3296-306. DOI:10.1158/1535-7163.MCT-09-0538
Debio 0932 ,CUDC-305 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Debio 0932 ,CUDC-305 manufacturers
- Product
- Debio 0932 ,CUDC-305 1061318-81-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23