HIF-1alpha/2alpha Inhibitor

Product Name: HIF-1alpha/2alpha Inhibitor
CAS No.: 329932-55-0
Chemical Name: HIF-1alpha/2alpha Inhibitor
Synonyms: FM19G11;FM 19G11 NEW;FM19G11 >=98% (HPLC);HIF-1alpha/2alpha Inhibitor;HIF-1α/2α Inhibitor IV, FM19G11;2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate;[2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate;3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester;Benzoic acid, 3-[(2,4-dinitrobenzoyl)amino]-, 2-(4-methylphenyl)-2-oxoethyl ester
CBNumber: CB32668403
Molecular Formula: C23H17N3O8
Formula Weight: 463.4
MOL File: 329932-55-0.mol

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HIF-1alpha/2alpha Inhibitor Property

storage temp.: 2-8°C
solubility: DMSO: ≥40mg/mL
form: powder
color: off-white to light brown

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F8807
Product name: FM19G11
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $67.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: F8807
Product name: FM19G11
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $543
Updated: 2024/03/01

Tocris

Product number: 6653
Product name: FM19G11
Purity: ≥98%(HPLC)
Packaging: 25
Price: $463
Updated: 2021/12/16

Tocris

Product number: 6653
Product name: FM19G11
Purity: ≥98%(HPLC)
Packaging: 5
Price: $119
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BF168364
Product name: FM 19G11 NEW
Packaging: 10mg
Price: $125
Updated: 2021/12/16

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HIF-1alpha/2alpha Inhibitor Chemical Properties,Usage,Production

Uses

FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):

to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line

Definition

ChEBI: 3-[[(2,4-dinitrophenyl)-oxomethyl]amino]benzoic acid [2-(4-methylphenyl)-2-oxoethyl] ester is a member of benzamides.

Biochem/physiol Actions

FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.

storage

Store at +4°C

HIF-1alpha/2alpha Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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HIF-1alpha/2alpha Inhibitor Suppliers

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329932-55-0, HIF-1alpha/2alpha InhibitorRelated Search:

FM19G11

HIF-1alpha/2alpha Inhibitor

[2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate

3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester

HIF-1α/2α Inhibitor IV, FM19G11

2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate

FM 19G11 NEW

Benzoic acid, 3-[(2,4-dinitrobenzoyl)amino]-, 2-(4-methylphenyl)-2-oxoethyl ester

FM19G11 >=98% (HPLC)

329932-55-0