4-fluorobicyclo[2.2.2]octane-1-carboxylic acid

Product Name: 4-fluorobicyclo[2.2.2]octane-1-carboxylic acid
CAS No.: 78385-84-9
Chemical Name: 4-fluorobicyclo[2.2.2]octane-1-carboxylic acid
Synonyms: 4-fluorobicyclo[2.2.2]octane-1-carboxylic acid;Bicyclo[2.2.2]octane-1-carboxylic acid, 4-fluoro-
CBNumber: CB32668812
Molecular Formula: C9H13FO2
Formula Weight: 172.2
MOL File: 78385-84-9.mol

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4-fluorobicyclo[2.2.2]octane-1-carboxylic acid Property

storage temp.: 2-8°C
Appearance: White Powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS56728
Product name: 4-Fluorobicyclo[2.2.2]octane-1-carboxylic acid
Purity: 97+%
Packaging: 100mg
Price: $414
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0418992
Product name: 4-FLUOROBICYCLO[2.2.2]OCTANE-1-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $451.86
Updated: 2021/12/16

AK Scientific

Product number: 0901CU
Product name: 4-Fluorobicyclo[2.2.2]octane-1-carboxylicacid
Packaging: 250mg
Price: $901
Updated: 2021/12/16

AK Scientific

Product number: 0901CU
Product name: 4-Fluorobicyclo[2.2.2]octane-1-carboxylicacid
Packaging: 500mg
Price: $1363
Updated: 2021/12/16

Matrix Scientific

Product number: 122478
Product name: 4-Fluorobicyclo[2.2.2]octane-1-carboxylicacid
Purity: 97.0%
Packaging: 1g
Price: $4752
Updated: 2021/12/16

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4-fluorobicyclo[2.2.2]octane-1-carboxylic acid Chemical Properties,Usage,Production

Synthesis

78385-85-0

78385-84-9

The general procedure for the synthesis of 4-fluorodicyclo[2.2.2]octane-1-carboxylic acid from the compound (CAS: 78385-85-0) is as follows: Preparation of intermediate A51C: To a solution of intermediate A51B (80 mg, 0.430 mmol) in methanol (2 mL) was added slowly and dropwise 1 M sodium hydroxide solution (1 mL, 1.00 mmol). The reaction mixture was stirred overnight at room temperature and subsequently concentrated. The residue was acidified with 1 N hydrochloric acid to pH about 2 and subsequently extracted with ethyl acetate. The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and filtered. Concentration of the filtrate gave the intermediate A51C (66 mg, 89% yield) as a white solid, which could be used in the next step of the reaction without further purification. 1H NMR (400 MHz, methanol-d4) δ ppm: 2.10-1.95 (m, 6H), 1.90-1.78 (m, 6H).

References

[1] Journal of Organic Chemistry, 1982, vol. 47, # 15, p. 2951 - 2957
[2] Patent: US9273058, 2016, B2. Location in patent: Page/Page column 529

4-fluorobicyclo[2.2.2]octane-1-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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78385-84-9, 4-fluorobicyclo[2.2.2]octane-1-carboxylic acidRelated Search:

4-fluorobicyclo[2.2.2]octane-1-carboxylic acid

Bicyclo[2.2.2]octane-1-carboxylic acid, 4-fluoro-

78385-84-9

C9H13FO2