8-chloroiMidazo[1,5-a]pyrazine
- Product Name
- 8-chloroiMidazo[1,5-a]pyrazine
- CAS No.
- 56468-23-6
- Chemical Name
- 8-chloroiMidazo[1,5-a]pyrazine
- Synonyms
- 8-chloroiMidazo[1,5-a]pyrazine;IMidazo[1,5-a]pyrazine, 8-chloro-
- CBNumber
- CB32669738
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 56468-23-6.mol
8-chloroiMidazo[1,5-a]pyrazine Property
- Melting point:
- 105-106 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.45±0.30(Predicted)
- Appearance
- Light yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C384403
- Product name
- 8-Chloroimidazo[1,5-a]pyrazine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C384403
- Product name
- 8-Chloroimidazo[1,5-a]pyrazine
- Packaging
- 50mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- C384403
- Product name
- 8-Chloroimidazo[1,5-a]pyrazine
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 3H32-5-BC
- Product name
- 8-Chloroimidazo[1,5-a]pyrazine
- Packaging
- 250mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- 5240BB
- Product name
- 8-Chloroimidazo[1,5-A]pyrazine
- Packaging
- 1g
- Price
- $955
- Updated
- 2021/12/16
8-chloroiMidazo[1,5-a]pyrazine Chemical Properties,Usage,Production
Synthesis
940307-81-3
56468-23-6
General procedure for the synthesis of 8-chloroimidazo[1,5-a]pyrazine from N-[(3-chloropyrazin-2-yl)methyl]formamide: To a solution of acetonitrile (5 mL) of the product of step 1 (200 mg, 1.17 mmol) was added N,N-dimethylformamide (0.5 mL) and phosphorous triclosan (0.5 mL). The reaction mixture was stirred at 60°C for 30 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove phosphorous trichloride. The residue was poured into water (5 mL), stirred for 20 minutes, and then extracted with ethyl acetate (5 mL x 5). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure to afford 8-chloroimidazo[1,5-a]pyrazine (40 mg) as a yellow solid. Analyzed by liquid chromatography-mass spectrometry (LC-MS), the molecular ion peak m/z (M + H)+ was measured to be 154.1, which was consistent with the theoretical value of 154.1.
References
[1] Patent: WO2007/64993, 2007, A2. Location in patent: Page/Page column 84
[2] Patent: WO2016/106623, 2016, A1. Location in patent: Page/Page column 111
[3] Patent: WO2016/101119, 2016, A1. Location in patent: Page/Page column 102; 103
[4] Patent: CN108191871, 2018, A. Location in patent: Paragraph 0200; 0207-0209
8-chloroiMidazo[1,5-a]pyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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