Cardiolipin (CL), (sodiuM or aMMoniuM salt) (bovine) Property

storage temp. 

-20°C

form 

Oil

color 

Orange to red

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

Cardiolipin (CL), (sodiuM or aMMoniuM salt) (bovine) Chemical Properties,Usage,Production

Uses

Heart CA has been used in the Mycobacterium lipid extraction and in β- Hexosaminidase release and calcium mobilization assays. It maybe used for liposome synthesis. It may also be used as a lipid standard for the in situ analysis and characterization of cardiolipins.

Uses

Heart CA has been used as a standard stock solution for its quantitative analysis using liquid chromatography?mass spectrometry (LC-MS)/MS. It has also been used for liposome preparation.

General Description

Cardiolipin is a phospholipid found in the inner membrane of the mitochondria. It is synthesized from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. It consists of two phosphatidyl residues, which are linked by a glycerol group.

Biochem/physiol Actions

Cardiolipin is involved in maintaining the structure and function of the mitochondria. It also serves as a co-factor for stimulating mitochondrial enzymes and mediates mitochondrial apoptosis. Cardiolipin is associated with the oxidative phosphorylation system for the adenine triphosphate (ATP) synthesis in the inner membrane of the mitochondria. Deficiency of cardiolipin is associated with variation of mitochondrial membrane structure and function. It is also associated with Barth syndrome.