GNF179 Metabolite

Product Name: GNF179 Metabolite
CAS No.: 1310455-86-7
Chemical Name: GNF179 Metabolite
Synonyms: EOS-60885;GNF179 Metabolite;2-(4-fluorophenyl)-8,8-dimethyl-6,7-dihydro-5H-imidazo[1,2-a]pyrazine;2-(4-fluorophenyl)-8,8-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-8,8-dimethyl-
CBNumber: CB32674428
Molecular Formula: C14H16FN3
Formula Weight: 245.3
MOL File: 1310455-86-7.mol

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GNF179 Metabolite Property

Boiling point:: 428.6±40.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 8.43±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Crysdot

Product number: CD31003928
Product name: GNF179Metabolite
Purity: 98+%
Packaging: 5mg
Price: $228
Updated: 2021/12/16

Crysdot

Product number: CD31003928
Product name: GNF179Metabolite
Purity: 98+%
Packaging: 10mg
Price: $326
Updated: 2021/12/16

Crysdot

Product number: CD31003928
Product name: GNF179Metabolite
Purity: 98+%
Packaging: 50mg
Price: $977
Updated: 2021/12/16

Crysdot

Product number: CD31003928
Product name: GNF179Metabolite
Purity: 98+%
Packaging: 100mg
Price: $1367
Updated: 2021/12/16

AccelPharmtech

Product number: E3170
Product name: 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-8,8-dimethyl-Imidazo[1,2-a]pyrazine
Purity: 97.00%
Packaging: 1G
Price: $1760
Updated: 2021/12/16

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GNF179 Metabolite Chemical Properties,Usage,Production

Uses

GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. IC50 value: Target: Anti-parasitic agent GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not.

References

[1] Meister S, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 9;334(6061):1372-7. DOI:10.1126/science.1211936

GNF179 Metabolite Preparation Products And Raw materials

Raw materials

Preparation Products

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GNF179 Metabolite Suppliers

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1310455-86-7, GNF179 MetaboliteRelated Search:

GNF179 Metabolite

2-(4-fluorophenyl)-8,8-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

EOS-60885

Imidazo[1,2-a]pyrazine, 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-8,8-dimethyl-

2-(4-fluorophenyl)-8,8-dimethyl-6,7-dihydro-5H-imidazo[1,2-a]pyrazine

1310455-86-7