ChemicalBook > CAS DataBase List > HG-9-91-01

HG-9-91-01

Product Name
HG-9-91-01
CAS No.
1456858-58-4
Chemical Name
HG-9-91-01
Synonyms
H -9-91-01;HG-9-91-01;SIK INHIBITOR 1;Salt-inducible Kinase (SIK),HG99101,SIK inhibitor-1,SIK inhibitor1,inhibit,HG 9 91 01,Inhibitor;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]urea;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea;N-(2,4-Dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]urea;Urea, N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-
CBNumber
CB32676109
Molecular Formula
C32H37N7O3
Formula Weight
567.68
MOL File
1456858-58-4.mol
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HG-9-91-01 Property

Boiling point:
790.8±60.0 °C(Predicted)
Density 
1.257±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥56.8 mg/mL in DMSO; ≥27.3 mg/mL in EtOH; ≥6.35 mg/mL in H2O with ultrasonic
form 
Powder
pka
13.11±0.70(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19179
Product name
HG-9-91-01
Purity
≥95%
Packaging
500μg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
19179
Product name
HG-9-91-01
Purity
≥95%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
19179
Product name
HG-9-91-01
Purity
≥95%
Packaging
5mg
Price
$505
Updated
2024/03/01
Cayman Chemical
Product number
19179
Product name
HG-9-91-01
Purity
≥95%
Packaging
10mg
Price
$884
Updated
2024/03/01
ApexBio Technology
Product number
B1052
Product name
HG-9-91-01
Packaging
50mg
Price
$795
Updated
2021/12/16
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HG-9-91-01 Chemical Properties,Usage,Production

Definition

ChEBI: HG-9-91-01 is a member of the class of phenylureas that is a potent inhibitor of salt-inducible kinase 2, a potential target protein for therapy in ovarian cancer. It has a role as an antineoplastic agent and a salt-inducible kinase 2 inhibitor. It is a dimethoxybenzene, an aminopyrimidine, a N-arylpiperazine, a N-alkylpiperazine, a secondary amino compound and a member of phenylureas.

Biological Activity

hg-9-91-01 is a pan-sik (salt-inducible kinases) inhibitor with ic50 values of 0.92nm, 6.6nm and 9.6nm for sik1, sik2, sik3, respectively [1].siks restrict the formation of regulatory macrophages. the inhibition of these enzymes is thought to have potential for treating inflammatory and autoimmune diseases. hg-9-91-01 potently inhibits siks through targeting both the atp-binding site and the small hydrophobic pocket. it is reported that, besides siks, hg-9-91-01 also inhibits various protein tyrosine kinases such as src, btk, fgf and ephrin receptors. but other ampk-related kinase subfamily members are not sensitive to hg-9-91-01. hg-9-91-01 can promote lps-stimulated il-10 production, creb-dependent gene transcription, inhibit proinflammatory cytokine secretion and induce the expression of regulatory macrophage markers [1].

References

[1] clark k, mackenzie k f, petkevicius k, et al. phosphorylation of crtc3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. proceedings of the national academy of sciences, 2012, 109(42): 16986-16991.

HG-9-91-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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HG-9-91-01 Suppliers

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1456858-58-4, HG-9-91-01Related Search:

N-Methylaniline N,N-DIMETHYLHYDROXYLAMINE HYDROCHLORIDE N,N'-Dimethyl-1,3-propanediamine N,N-Dimethylbenzylamine N,N-Dimethylbenzamide N,N-Dimethylpropionamide

  • HG-9-91-01
  • N-(2,4-Dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]urea
  • 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea
  • SIK INHIBITOR 1
  • 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]urea
  • Urea, N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-
  • Salt-inducible Kinase (SIK),HG99101,SIK inhibitor-1,SIK inhibitor1,inhibit,HG 9 91 01,Inhibitor
  • H -9-91-01
  • 1456858-58-4
  • API