HG-9-91-01
- Product Name
- HG-9-91-01
- CAS No.
- 1456858-58-4
- Chemical Name
- HG-9-91-01
- Synonyms
- HG-9-91-01;SIK INHIBITOR 1;Salt-inducible Kinase (SIK),HG99101,SIK inhibitor-1,SIK inhibitor1,inhibit,HG 9 91 01,Inhibitor;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]urea;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea;N-(2,4-Dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]urea;Urea, N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-
- CBNumber
- CB32676109
- Molecular Formula
- C32H37N7O3
- Formula Weight
- 567.68
- MOL File
- 1456858-58-4.mol
HG-9-91-01 Property
- Boiling point:
- 790.8±60.0 °C(Predicted)
- Density
- 1.257±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥56.8 mg/mL in DMSO; ≥27.3 mg/mL in EtOH; ≥6.35 mg/mL in H2O with ultrasonic
- form
- Powder
- pka
- 13.11±0.70(Predicted)
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19179
- Product name
- HG-9-91-01
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 19179
- Product name
- HG-9-91-01
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 19179
- Product name
- HG-9-91-01
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- 19179
- Product name
- HG-9-91-01
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $884
- Updated
- 2024/03/01
- Product number
- B1052
- Product name
- HG-9-91-01
- Packaging
- 50mg
- Price
- $795
- Updated
- 2021/12/16
HG-9-91-01 Chemical Properties,Usage,Production
Definition
ChEBI: HG-9-91-01 is a member of the class of phenylureas that is a potent inhibitor of salt-inducible kinase 2, a potential target protein for therapy in ovarian cancer. It has a role as an antineoplastic agent and a salt-inducible kinase 2 inhibitor. It is a dimethoxybenzene, an aminopyrimidine, a N-arylpiperazine, a N-alkylpiperazine, a secondary amino compound and a member of phenylureas.
Biological Activity
hg-9-91-01 is a pan-sik (salt-inducible kinases) inhibitor with ic50 values of 0.92nm, 6.6nm and 9.6nm for sik1, sik2, sik3, respectively [1].siks restrict the formation of regulatory macrophages. the inhibition of these enzymes is thought to have potential for treating inflammatory and autoimmune diseases. hg-9-91-01 potently inhibits siks through targeting both the atp-binding site and the small hydrophobic pocket. it is reported that, besides siks, hg-9-91-01 also inhibits various protein tyrosine kinases such as src, btk, fgf and ephrin receptors. but other ampk-related kinase subfamily members are not sensitive to hg-9-91-01. hg-9-91-01 can promote lps-stimulated il-10 production, creb-dependent gene transcription, inhibit proinflammatory cytokine secretion and induce the expression of regulatory macrophage markers [1].
References
[1] clark k, mackenzie k f, petkevicius k, et al. phosphorylation of crtc3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. proceedings of the national academy of sciences, 2012, 109(42): 16986-16991.
HG-9-91-01 Preparation Products And Raw materials
Raw materials
Preparation Products
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