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Paprotrain

Product Name
Paprotrain
CAS No.
57046-73-8
Chemical Name
Paprotrain
Synonyms
Paprotrain;Kinesin,Paprotrain,Inhibitor,inhibit;2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile;(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile;(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-;(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
CBNumber
CB32677878
Molecular Formula
C16H11N3
Formula Weight
245.28
MOL File
57046-73-8.mol
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Paprotrain Property

Melting point:
202℃
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml; Ethanol: 0.2 mg/ml
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10524
Product name
Paprotrain
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10524
Product name
Paprotrain
Purity
≥95%
Packaging
5mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
10524
Product name
Paprotrain
Purity
≥95%
Packaging
10mg
Price
$78
Updated
2024/03/01
Tocris
Product number
4813
Product name
Paprotrain
Purity
≥99%(HPLC)
Packaging
10
Price
$81
Updated
2021/12/16
Tocris
Product number
4813
Product name
Paprotrain
Purity
≥99%(HPLC)
Packaging
50
Price
$342
Updated
2021/12/16
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Paprotrain Chemical Properties,Usage,Production

Description

Mitotic kinesin-like protein 2 (MKLP-2) is an N-terminal motor from the kinesin-6 family that is essential for normal cleavage furrow ingression and cytokinesis. Its activity mediates the relocation of the chromosome passenger proteins Aurora B kinase and survivin from the centromeres to the central spindle in anaphase cells in order to facilitate cytokinesis, avoiding the generation of binucleated cells. Paprotrain, PAssenger PROteins TRAnsport INhibitor, is the first known inhibitor of MKLP-2. It is a cell-permeable, reversible inhibitor uncompetitive with ATP (Ki = 3.4 μM) and noncompetitive with microtubules (Ki = 1.6 μM), demonstrating ATPase inhibition of basal and microtubule-stimulated activities with IC50 values of 1.35 and 0.83 μM, respectively. Paprotrain does not inhibit twelve additional kinesins, including the closely related kinesin-6 motors MKLP-1 and MPP1. Incubation with 10-50 μM paprotrain results in binucleated cells, perturbing relocation of Aurora B kinase and survivin without affecting microtubule polymerization.

Uses

Paprotrain is a cell-permeable inhibitor of the kinesin-6 family member KIF20A (MKLP-2).

Paprotrain Preparation Products And Raw materials

Raw materials

Preparation Products

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Paprotrain Suppliers

China 41 United Kingdom 2 United States 8 USA 1 Global 52

57046-73-8, PaprotrainRelated Search:

METHYLENECYCLOHEXANE Nicotinamide

  • Paprotrain
  • (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
  • 2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile
  • (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
  • 1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-
  • Kinesin,Paprotrain,Inhibitor,inhibit
  • (Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile
  • 57046-73-8