ChemicalBook > CAS DataBase List > N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine

N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine

Product Name
N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine
CAS No.
1227634-69-6
Chemical Name
N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine
Synonyms
NF351;GNF351, 10 mM in DMSO;AhR Antagonist III, GNF351;GNF351,Inhibitor,AhR,GNF-351,Aryl Hydrocarbon Receptor,GNF 351,inhibit;N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine;9H-Purin-6-amine, N-[2-(1H-indol-3-yl)ethyl]-9-(1-methylethyl)-2-(5-methyl-3-pyridinyl)-
CBNumber
CB32682775
Molecular Formula
C24H25N7
Formula Weight
411.5
MOL File
1227634-69-6.mol
More
Less

N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine Property

Boiling point:
606.8±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 125 mg/mL (303.77 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
pka
17.15±0.30(Predicted)
color 
Off-white to light yellow
InChI
1S/C24H25N7/c1-15(2)31-14-28-21-23(26-9-8-17-13-27-20-7-5-4-6-19(17)20)29-22(30-24(21)31)18-10-16(3)11-25-12-18/h4-7,10-15,27H,8-9H2,1-3H3,(H,26,29,30)
InChIKey
ABXIUYMKZDZUDC-UHFFFAOYSA-N
SMILES
[n]1(c2nc(nc(c2nc1)NCCc4c5c([nH]c4)cccc5)c3cncc(c3)C)C(C)C
More
Less

Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0022634
Product name
GNF351
Purity
99.90%
Packaging
5mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0022634
Product name
GNF351
Purity
99.90%
Packaging
10mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0022634
Product name
GNF351
Purity
99.90%
Packaging
25mg
Price
$380
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0009225
Product name
GNF351
Purity
95.00%
Packaging
5MG
Price
$458.5
Updated
2021/12/16
ChemScene
Product number
CS-0022634
Product name
GNF351
Purity
99.90%
Packaging
50mg
Price
$680
Updated
2021/12/16
More
Less

N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine Chemical Properties,Usage,Production

Uses

A cell-permeable purine compound that acts as a high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC50 = 62 nM in mouse liver cytosol expressing humanized AhR) and lacks any agonist activity even at higher doses. Reportedly binds with high affinity to the ligand-binding pocket of AhR and blocks the binding of an array of exogenous and endogenous ligands. Shown to non-covalently interact with Ser317, His291, and Ser365 in human and with Ser311, His285, and Ser359 in mouse AhR. Represses AhR transcriptional activity via the dioxin response element (DRE)-dependent and independent mediated responses in human and mouse cells (IC50 = 8.5 nM in HepG2 40/6 cells).

N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine Suppliers

China 34 United States 4 Global 38
ChemShuttle, Inc.
Tel
0510-83588313-811 18800520310
Email
sales@chemshuttle.com
Country
China
ProdList
2999
Advantage
62
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
89689
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
9697
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Changzhou Xuanye Technology Co., Ltd
Tel
15195022192
Email
279776773@qq.com
Country
China
ProdList
2000
Advantage
58
Wuxi Donghe Pharmaceutical Technology Co., Ltd.
Tel
63313187 15358055255
Fax
QQ：63313187
Email
63313187@qq.com
Country
China
ProdList
1985
Advantage
58

1227634-69-6, N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMineRelated Search:


  • N-(2-(1H-indol-3-yl)ethyl)-9-isopropyl-2-(5-Methylpyridin-3-yl)-9H-purin-6-aMine
  • 9H-Purin-6-amine, N-[2-(1H-indol-3-yl)ethyl]-9-(1-methylethyl)-2-(5-methyl-3-pyridinyl)-
  • GNF351,Inhibitor,AhR,GNF-351,Aryl Hydrocarbon Receptor,GNF 351,inhibit
  • NF351
  • GNF351, 10 mM in DMSO
  • AhR Antagonist III, GNF351
  • 1227634-69-6
  • C24H25N7