AMG 925

ChemicalBook > CAS DataBase List > AMG 925

Product Name: AMG 925
CAS No.: 1401033-86-0
Chemical Name: AMG 925
Synonyms: FLX925;FLX-925;AMG 925;CS-1594;FLX 925.;AMG 925 (FLX925;FLX925 (AMG-925);AMG 925;AMG925;AMG-925;AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.;2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-
CBNumber: CB32685918
Molecular Formula: C26H29N7O2
Formula Weight: 471.55
MOL File: 1401033-86-0.mol

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AMG 925 Property

Boiling point:: 712.3±70.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 13.41±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29245
Product name: AMG 925
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29245
Product name: AMG 925
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29245
Product name: AMG 925
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 29245
Product name: AMG 925
Packaging: 25mg
Price: $267
Updated: 2024/03/01

TRC

Product number: A604290
Product name: AMG925
Packaging: 50mg
Price: $310
Updated: 2021/12/16

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AMG 925 Chemical Properties,Usage,Production

Description

AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC₅₀s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC₅₀ = 2.22 μM). AMG 925 also binds to FLT3^ITD, FLT3^D835Y, FLT3^D835H, FLT3^K663Q, and FLT3^N841I (K_ds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC₅₀s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.

Uses

AMG 925 is a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3.

Definition

ChEBI: AMG-925 is an organic heterotricyclic compound that is 9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a trans-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML). It has a role as an antineoplastic agent, an apoptosis inducer, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a secondary amino compound, a tertiary amino compound, a naphthyridine derivative, a primary alpha-hydroxy ketone and an organic heterotricyclic compound.

target

FLT3

References

[1] keegan k, li c, li z, ma j, ragains m, coberly s, hollenback d, eksterowicz j, liang l, weidner m, huard j, wang x, alba g, orf j, lo mc, zhao s, ngo r, chen a, liu l, carlson t, quéva c, mcgee lr, medina j, kamb a, wickramasinghe d, dai k. preclinical evaluation of amg 925, a flt3/cdk4 dual kinase inhibitor for treating acute myeloid leukemia. mol cancer ther. 2014 apr;13(4):880-9.

AMG 925 Preparation Products And Raw materials

Raw materials

Preparation Products

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1401033-86-0, AMG 925Related Search:

AMG 925

1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone

2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-

Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-

AMG 925;AMG925;AMG-925

CS-1594

2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone

AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.

FLX 925.

FLX925

FLX-925

AMG 925 (FLX925

FLX925 (AMG-925)

CDK,AMG 925,Cluster of differentiation antigen 135,FLT3,Cyclin dependent kinase,inhibit,CD135,AMG-925,AMG925,Inhibitor,Fms like tyrosine kinase 3

1401033-86-0

C26H29N7O2