Afatinib iMpurity

ChemicalBook > CAS DataBase List > Afatinib iMpurity

Product Name: Afatinib iMpurity
CAS No.: 1680184-59-1
Chemical Name: Afatinib iMpurity
Synonyms: Cis-Afatinib;(2Z)-Afatinib;Afatinib (Z)-Isomer;Z-Afatinib? (Afatinib Impurity）;Afatinib Impurity B (2Z)-Afatinib;Afatinib Impurity 18（(2Z) Afatinib）;1-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2Z)-
CBNumber: CB32686692
Molecular Formula: C24H25ClFN5O3
Formula Weight: 485.94
MOL File: 1680184-59-1.mol

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Afatinib iMpurity Property

Melting point:: >134°C (dec.)
Boiling point:: 676.9±55.0 °C(Predicted)
Density: 1.380±0.06 g/cm3(Predicted)
storage temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 11.79±0.43(Predicted)
color: Pale Yellow to Light Yellow
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A355305
Product name: (2Z)-Afatinib
Packaging: 0.5mg
Price: $475
Updated: 2021/12/16

TRC

Product number: A355305
Product name: (2Z)-Afatinib
Packaging: 1mg
Price: $870
Updated: 2021/12/16

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Afatinib iMpurity Chemical Properties,Usage,Production

Uses

(2Z)-Afatinib is a structural analogue of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

Afatinib iMpurity Preparation Products And Raw materials

Raw materials

Preparation Products

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1680184-59-1, Afatinib iMpurityRelated Search:

Afatinib Impurity 3 Afatinib Impurity 19 Afatinib Impurity 7 Afatinib IMpurity F R-afatinib Afatinib Afatinib Impurity 10 N-(3-chloro-4-fluorophenyl)-7-Methoxy-6-nitroquinazolin-4-aMine 4-Hydroxy 4-Dedimethylamino Afatinib AfatinibHydrolytic impurity Afatinib Impurity 15 Afatinib Impurity 2 Afatinib Impurity 18 Afatinib Impurity 6 Afatinib IMpurity E Afatinib Impurity 9 Afatinib Impurity 14 Afatinib Impurity 17

(2Z)-Afatinib

Afatinib (Z)-Isomer

Cis-Afatinib

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2Z)-

Afatinib Impurity 18（(2Z) Afatinib）

1-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

Afatinib Impurity B (2Z)-Afatinib

Z-Afatinib? (Afatinib Impurity）

1680184-59-1