2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
- Product Name
- 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
- CAS No.
- 1181083-81-7
- Chemical Name
- 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
- Synonyms
- CLP-290;CLP 290;CLP290;CLP290, 10 mM in DMSO;inhibit,Potassium Channel,Inhibitor,CLP290,CLP 290,KcsA;[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine;2-([(5Z)-2-(1,2-DIAZINAN-1-YL)-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-5-YLIDENE]METHYL)-5-FLUOROPHENYL PYRROL;2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate;5-Fluoro-2-(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methylphenyl pyrrolidine-1-carboxylate;(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 5-fluoro-2-[(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-5(4H)-thiazolylidene]methyl]phenyl ester
- CBNumber
- CB32704143
- Molecular Formula
- C19H21FN4O3S
- Formula Weight
- 404.46
- MOL File
- 1181083-81-7.mol
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Property
- Boiling point:
- 553.7±60.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO:23.74(Max Conc. mg/mL);58.7(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);2.47(Max Conc. mM)
Ethanol:2.02(Max Conc. mg/mL);4.99(Max Conc. mM) - form
- A crystalline solid
- pka
- 1.29±0.20(Predicted)
- color
- Off-white to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 6758
- Product name
- CLP290
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $210
- Updated
- 2021/12/16
- Product number
- C587524
- Product name
- CLP-290
- Packaging
- 50mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- C587524
- Product name
- CLP-290
- Packaging
- 250mg
- Price
- $920
- Updated
- 2021/12/16
- Product number
- CS-0023300
- Product name
- CLP290
- Purity
- 99.83%
- Packaging
- 50mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-0023300
- Product name
- CLP290
- Purity
- 99.83%
- Packaging
- 25mg
- Price
- $260
- Updated
- 2021/12/16
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Chemical Properties,Usage,Production
Uses
CLP-290 is a chloride extrusion enhancer.
in vivo
CLP290 (oral gavage; 100 mg/kg; twice a day; 7 day) enhances KCC2 activity and restores Cl- transport in superficial dorsal horn (SDH) neurons of morphine-treated rats, and prevents morphine-induced hyperalgesia (MIH) in rat[1].
| Animal Model: | Adult male rats (300?g, >postnatal day 60)[1] |
| Dosage: | 100 mg/kg |
| Administration: | Oral gavage; 100 mg/kg; twice a day; 7day |
| Result: | Rescued established MIH and prevented its development by restoring Cl-?transport or preventing its deficiency in the SDH. |
storage
Store at -20°C
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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