(5-Fluorobenzofuran-2-yl)boronic acid

Product Name: (5-Fluorobenzofuran-2-yl)boronic acid
CAS No.: 473416-33-0
Chemical Name: (5-Fluorobenzofuran-2-yl)boronic acid
Synonyms: 5-fluorobenzofuran-2-boronic acid;(5-Flufuran-2-based) boronic acid;5-Fluorobenzofurane-2-boronic Acid;(5-Fluorobenzofuran-2-yl)boronic acid;Boronic acid, (5-fluoro-2-benzofuranyl)- (9CI)
CBNumber: CB32710128
Molecular Formula: C8H6BFO3
Formula Weight: 179.94
MOL File: 473416-33-0.mol

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(5-Fluorobenzofuran-2-yl)boronic acid Property

Boiling point:: 343.8±45.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
pka: 5.88±0.30(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F593865
Product name: (5-Fluoro-2-benzofuranyl)boronicAcid
Packaging: 10mg
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: PC535073
Product name: (5-Fluorobenzofuran-2-yl)boronicacid
Purity: 98%
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC535073
Product name: (5-Fluorobenzofuran-2-yl)boronicacid
Purity: 98%
Packaging: 250mg
Price: $96
Updated: 2021/12/16

AK Scientific

Product number: 1650DA
Product name: (5-Fluorobenzofuran-2-yl)boronicacid
Packaging: 250mg
Price: $222
Updated: 2021/12/16

AK Scientific

Product number: 1650DA
Product name: (5-Fluorobenzofuran-2-yl)boronicacid
Packaging: 1g
Price: $431
Updated: 2021/12/16

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(5-Fluorobenzofuran-2-yl)boronic acid Chemical Properties,Usage,Production

Uses

(5-Fluoro-2-benzofuranyl)boronic Acid serves as a reagent for the preparation of heterocyclic compounds for the inhibition of PASK useful for the treatment of diseases like diabetes mellitus.

Synthesis

24410-59-1

5419-55-6

473416-33-0

Step 3. Synthesis of (5-fluorofuran-2-yl)boronic acid Tetramethylethylenediamine (10.2 g, 87.93 mmol) was added to an anhydrous tetrahydrofuran (250 mL) solution of 5-fluorobenzofuran (10 g, 73.53 mmol). The reaction system was cooled to below -60 °C under nitrogen protection and n-butyllithium (93.75 mmol, 2.5 M hexane solution) was slowly added dropwise. After the dropwise addition, the reaction mixture was slowly warmed up to -10 °C over 45 min and stirring was continued at this temperature for 30 min. Subsequently, the reaction system was cooled again to below -60°C and triisopropyl borate (41.4 g, 220.21 mmol) was slowly added dropwise. After completion of the dropwise addition, the reaction mixture was gradually warmed to room temperature, the reaction was quenched with 2N hydrochloric acid (70 mL) and stirred for 1 hour. The pH of the aqueous layer was adjusted to 5 with sodium hydroxide solution and extracted with ethyl acetate (3 x 80 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the crude product (5-fluorofuran-2-yl)boronic acid (3.5 g, 26% yield), which could be used in the next reaction without further purification. 1H-NMR (300MHz, CDCl3): δ8.63 (s, 2H), 7.58-7.62 (m, 1H), 7.44-7.49 (m, 2H), 7.15-7.22 (m, 1H).

References

[1] Patent: US2012/225863, 2012, A1. Location in patent: Page/Page column 17-18

(5-Fluorobenzofuran-2-yl)boronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-Fluorobenzofuran-2-yl)boronic acid Suppliers

China 31 India 2 United States 3 Global 36

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473416-33-0, (5-Fluorobenzofuran-2-yl)boronic acidRelated Search:

(5-Fluorobenzofuran-2-yl)boronic acid

5-fluorobenzofuran-2-boronic acid

Boronic acid, (5-fluoro-2-benzofuranyl)- (9CI)

5-Fluorobenzofurane-2-boronic Acid

(5-Flufuran-2-based) boronic acid

473416-33-0

C8H6BFO3

Organic boronic acid