ChemicalBook > CAS DataBase List > FADROZOLE
FADROZOLE
- Product Name
- FADROZOLE
- CAS No.
- 102676-47-1
- Chemical Name
- FADROZOLE
- Synonyms
- Afema;FAD286;CS-2710;FAD 286);CGS-16949;FADROZOLE;CGS-169494;FADROZOLE USP/EP/BP;Fadrozole (CGS 16949A;Fadrozole, 10 mM in DMSO
- CBNumber
- CB3271421
- Molecular Formula
- C14H13N3
- Formula Weight
- 223.27
- MOL File
- 102676-47-1.mol
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FADROZOLE Property
- Melting point:
- 0°C
- Boiling point:
- 0°C
- Density
- 1.20
- Flash point:
- 0°C
- storage temp.
- 2-8°C
- solubility
- DMSO : ≥ 100 mg/mL (447.89 mM)
- form
- Solid
- pka
- 7.16±0.40(Predicted)
- color
- White to off-white
- EPA Substance Registry System
- Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)- (102676-47-1)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P281Use personal protective equipment as required.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- API0002673
- Product name
- FADROZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $975.45
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0002673
- Product name
- FADROZOLE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1855.51
- Updated
- 2021/12/16
Arctom
- Product number
- AS554511
- Product name
- 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $39
- Updated
- 2021/12/16
Ambeed
- Product number
- A428094
- Product name
- 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $71
- Updated
- 2021/12/16
Ambeed
- Product number
- A428094
- Product name
- 4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
- Purity
- 95+%
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
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FADROZOLE Chemical Properties,Usage,Production
Chemical Properties
Melting point 117-118°C.
Fadrozole Hydrochloride: C14H13N3·HCl. [102676-96-0]. Crystallized from isopropyl alcohol, melting point 231-233°C. Soluble in water.
Uses
Antineoplastic
Definition
ChEBI: 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile is an imidazopyridine.
in vivo
Fadrozole hydrochloride is able to inhibit the aromatase-mediated androstenedione-induced uterine hypertrophy in immature female rats with an ED50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED50 of 30 mg/kg when given orally[1]. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars dta mas in female rats, and reduces the of spontaneous hcu ar tumours in male and female rats[2]. Administration of fadrozole in male and female mice suppresses the production of 17b-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole treatment returns these levels to baseline values[3].
IC 50
Aromatase
FADROZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from FADROZOLE manufacturers
Dideu Industries Group Limited
- Product
- FADROZOLE 102676-47-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-02
Shaanxi Dideu Medichem Co. Ltd
- Product
- Fadrozole 102676-47-1
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 800 ton
- Release date
- 2020-04-30