EPI 743
- Product Name
- EPI 743
- CAS No.
- 1213269-98-7
- Chemical Name
- EPI 743
- Synonyms
- EPI 743;Vatiquinone;Vatiquinone (EPI743);alpha-Tocotrienol quinone. ATQ3;2-[(3R,6E,10E)-3-Hydroxy-3,7,11,15-tetramethyl-6,10,14-hexadecatrien-1-yl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione;2,5-Cyclohexadiene-1,4-dione, 2-[(3R,6E,10E)-3-hydroxy-3,7,11,15-tetramethyl-6,10,14-hexadecatrien-1-yl]-3,5,6-trimethyl-
- CBNumber
- CB32717758
- Molecular Formula
- C29H44O3
- Formula Weight
- 440.65786
- MOL File
- 1213269-98-7.mol
EPI 743 Property
- Boiling point:
- 565.6±39.0 °C(Predicted)
- Density
- 0.978±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Ethanol:10.0(Max Conc. mg/mL);22.69(Max Conc. mM)
- form
- Liquid
- pka
- 14.88±0.29(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 3457DG
- Product name
- Vatiquinone
- Packaging
- 5mg
- Price
- $256
- Updated
- 2021/12/16
EPI 743 Chemical Properties,Usage,Production
Uses
EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione[1][2].
Biological Activity
Vatiquinone (EPI-743), a metabolite of a-tocotrienol, is an orally available and highly potent analog of coenzyme Q10 th at modulates the activity of oxidoreductases including AD(P)H:quinone oxidoreductase 1, resulting in increased cellular GSH concentration and improvement in redox status. Vatiquinone is an agent designated to tre at mitochondrial diseases.
References
[1] Kouga T, et al. Japanese Leigh syndrome case treated with EPI-743. Brain Dev. 2018 Feb;40(2):145-149. Brain Dev. 2018 Feb;40(2):145-149. DOI:10.1016/j.braindev.2017.08.005
[2] Avula S, et al. Treatment of Mitochondrial Disorders. Curr Treat Options Neurol. 2014. 16:292.
[3] Kahn-Kirby AH, et al. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy. PLoS One. 2019 Mar 28;14(3):e0214250. DOI:10.1371/journal.pone.0214250
EPI 743 Preparation Products And Raw materials
Raw materials
Preparation Products
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