8-Azabicyclo[3.2.1]octane hydrochloride
- Product Name
- 8-Azabicyclo[3.2.1]octane hydrochloride
- CAS No.
- 6760-99-2
- Chemical Name
- 8-Azabicyclo[3.2.1]octane hydrochloride
- Synonyms
- 8-Azabicyclo[3.2.1]octane HCl;8-Azabicyclo[3.2.1]octane hydrochloride 95+%;8-Azabicyclo[3.2.1]octane, hydrochloride (1:1)
- CBNumber
- CB32723304
- Molecular Formula
- C7H14ClN
- Formula Weight
- 147.64576
- MOL File
- 6760-99-2.mol
8-Azabicyclo[3.2.1]octane hydrochloride Property
- Melting point:
- 307-308 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H13N.ClH/c1-2-6-4-5-7(3-1)8-6;/h6-8H,1-5H2;1H
- InChIKey
- VAINBTSWOOHLOV-UHFFFAOYSA-N
- SMILES
- C12NC(CC1)CCC2.[H]Cl
Safety
- HS Code
- 2904200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A800760
- Product name
- 8-Azabicyclo[3.2.1]octaneHydrochloride
- Packaging
- 2.5mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H31-5-30
- Product name
- 8-Azabicyclo[3.2.1]octanehydrochloride
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 3752AJ
- Product name
- 8-Azabicyclo[3.2.1]octanehydrochloride
- Packaging
- 1g
- Price
- $501
- Updated
- 2021/12/16
- Product number
- 3H31-5-30
- Product name
- 8-Azabicyclo[3.2.1]octanehydrochloride
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- FA161474
- Product name
- 8-Azabicyclo[3.2.1]octane HCl
- Packaging
- 250mg
- Price
- $750
- Updated
- 2021/12/16
8-Azabicyclo[3.2.1]octane hydrochloride Chemical Properties,Usage,Production
Synthesis
529-17-9
6760-99-2
Example 126 Preparation of 3-{4-[3-(8-azabicyclo[3.2.1]oct-8-yl)propoxy]phenyl}-2-methyl-4(3H)-quinazolinone: (1) Synthesis of 8-azabicyclo[3.2.1]octane hydrochloride: scopoletane (11.0 mL, 7.44 mmol) was dissolved in toluene (10 mL), chlorinated ethyl carbonate (2.2 mL, 23 mmol) was added slowly, and the reaction mixture was stirred for 24 hours at 80 °C. After completion of the reaction, distilled water was added to the mixture and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting oily residue was dissolved in concentrated hydrochloric acid (10 mL) and heated at 100 °C with stirring for 2 hours. At the end of the reaction, the solvent was removed by distillation under reduced pressure, toluene was added to the residue and distilled again under reduced pressure to give the target product 8-azabicyclo[3.2.1]octane hydrochloride (820 mg, 72% yield) as a colorless solid.
References
[1] Patent: US2005/182045, 2005, A1. Location in patent: Page/Page column 53
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 15, p. 3861 - 3864
[3] Journal of the American Chemical Society, 1996, vol. 118, # 44, p. 10819 - 10823
8-Azabicyclo[3.2.1]octane hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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