ChemicalBook > CAS DataBase List > FMoc-Val-Cit-PAB-MMAE

FMoc-Val-Cit-PAB-MMAE

Product Name
FMoc-Val-Cit-PAB-MMAE
CAS No.
1350456-56-2
Chemical Name
FMoc-Val-Cit-PAB-MMAE
Synonyms
Fmoc-VC-PAB-MMAE;FMoc-Val-Cit-PAB-MMAE;Fmoc-Val-Cit-PABC-MMAE;Drug-Linker Conjugates for ADC,inhibit,FmocValCitPABMMAE,Inhibitor,Fmoc Val Cit PAB MMAE;L-Valinamide, N-[[[4-[[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-meth...;N-[[[4-[[N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide;{4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]pentanamido]phenyl}methyl N-[(1S)-1-{[(1S)-1-{[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl]-N-methylcarbamate
CBNumber
CB32730902
Molecular Formula
C73H104N10O14
Formula Weight
1345.67
MOL File
1350456-56-2.mol
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FMoc-Val-Cit-PAB-MMAE Property

Boiling point:
1353.5±65.0 °C(Predicted)
Density 
1.198±0.06 g/cm3(Predicted)
pka
10.63±0.46(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5428
Product name
Fmoc-Val-Cit-PAB-MMAE
Purity
95.05%
Packaging
1mg
Price
$420
Updated
2021/12/16
BroadPharm
Product number
BP-23246
Product name
Fmoc-Val-Cit-PAB-MMAE
Purity
98%
Packaging
10mg
Price
$890
Updated
2021/12/16
ChemScene
Product number
CS-5428
Product name
Fmoc-Val-Cit-PAB-MMAE
Purity
95.05%
Packaging
5mg
Price
$1020
Updated
2021/12/16
ChemScene
Product number
CS-5428
Product name
Fmoc-Val-Cit-PAB-MMAE
Purity
95.05%
Packaging
10mg
Price
$1620
Updated
2021/12/16
Crysdot
Product number
CD31003790
Product name
Fmoc-Val-Cit-PAB-MMAE
Purity
98+%
Packaging
10mg
Price
$937
Updated
2021/12/16
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FMoc-Val-Cit-PAB-MMAE Chemical Properties,Usage,Production

Description

Fmoc-Val-Cit-PAB-MMAE is a type of small molecule drug that can selectively target cancer cells while minimizing damage to healthy cells. The Fmoc group is a commonly used protective group in peptide synthesis and is often used to protect N-terminal amino groups. Val and Cit groups are common amino acids in peptides and proteins. The Fmoc group protects the amino group and helps to ensure that the drug is delivered intact to its target, while the Val and Cit amino acids provide a binding site for the drug to target specific cancer cells. The PAB linker (a para-aminobenzoic acid group) ensures that the MMAE cytotoxic drug is delivered specifically to cancer cells, where it can exert its toxic effects and inhibit the growth of cancer cells.

Uses

Fmoc-Val-Cit-PAB-MMAE is a precursor of antibody drug conjugate containing a cleavable Val-Cit peptide, a PABC linker and a MMAE payload. It can be attached to a monoclonal antibody (MAB) which directs it toward cancer cells.

Preparation

Fmoc-Val-Cit-PAB-PNP (388.4 mg,0.507 mmol) was dissolved in DMF (40 ml) at 0 ℃ under nitrogen protection and then HOBt (68.4 mg,0.507 mmol) and MMAE (400.0 mg,0.558 mmol) were added. After 15 min, pyridine (8 ml) and DIPEA (106.2 mL, 0.608 mmol) were added and reached 0 ℃ for 30 min. Then warmed to room temperature and stirred for 3 hours. DIPEA (106.2. mL, 0.608 mmol) was added and the reaction was continued for 24 h. After the reaction was complete, the mixture was concentrated in vacuo. The crude product was purified by column chromatography to give Fmoc-Val-Cit-PAB-MMAE as a white solid.

FMoc-Val-Cit-PAB-MMAE Preparation Products And Raw materials

Raw materials

Preparation Products

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FMoc-Val-Cit-PAB-MMAE Suppliers

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View Lastest Price from FMoc-Val-Cit-PAB-MMAE manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Fmoc-Val-Cit-PAB-MMAE 1350456-56-2
Price
US $0.00/mg
Min. Order
250mg
Purity
>98.00%
Supply Ability
250mg
Release date
2024-03-29

1350456-56-2, FMoc-Val-Cit-PAB-MMAERelated Search:


  • FMoc-Val-Cit-PAB-MMAE
  • L-Valinamide, N-[[[4-[[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-meth...
  • Fmoc-Val-Cit-PABC-MMAE
  • Fmoc-VC-PAB-MMAE
  • N-[[[4-[[N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
  • Drug-Linker Conjugates for ADC,inhibit,FmocValCitPABMMAE,Inhibitor,Fmoc Val Cit PAB MMAE
  • {4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]pentanamido]phenyl}methyl N-[(1S)-1-{[(1S)-1-{[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-2-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]carbamoyl}-1-methoxy-2-methylethyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl](methyl)carbamoyl}-2-methylpropyl]carbamoyl}-2-methylpropyl]-N-methylcarbamate
  • 1350456-56-2
  • C73H104N10O14
  • ADCs
  • ADC LINKER