K-7174

Product Name: K-7174
CAS No.: 191089-59-5
Chemical Name: K-7174
Synonyms: K-7174;K7174; K 7174;K-7174(FREE BASE);K-7174,K 7174,inhibit,K7174,Inhibitor;1,4-Bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane , K-7174;1H-1,4-Diazepine, hexahydro-1,4-bis[(4E)-5-(3,4,5-trimethoxyphenyl)-4-penten-1-yl]-
CBNumber: CB32731080
Molecular Formula: C33H48N2O6
Formula Weight: 568.74
MOL File: 191089-59-5.mol

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K-7174 Property

Boiling point:: 689.9±55.0 °C(Predicted)
Density: 1.074±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 9.60±0.10(Predicted)
form: Oil
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611722
Product name: K-7174
Packaging: 10mg
Price: $324.7
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611722
Product name: K-7174
Packaging: 50mg
Price: $569.5
Updated: 2021/12/16

Crysdot

Product number: CD31002841
Product name: K-7174
Purity: 98+%
Packaging: 5mg
Price: $76
Updated: 2021/12/16

Crysdot

Product number: CD31002841
Product name: K-7174
Purity: 98+%
Packaging: 10mg
Price: $115
Updated: 2021/12/16

DC Chemicals

Product number: DC23944
Product name: K-7174
Purity: >98%
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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K-7174 Chemical Properties,Usage,Production

Uses

K-7174 is an orally active proteasome and GATA inhibitor. K-7174 is a cell adhesion inhibitor. K-7174 induces cell apoptosis. K-7174 shows antitumor activities, it can be used for the research of cancer[1][2][3].

in vivo

K-7174 (30 mg/kg; i.p. once daily for 9 days) reverses the decreasing of hemoglobin concentrations and reticulocyte counts by IL-1β or TNF-α^[2]. K-7174 (75 mg/kg; i.p. once daily for 14 days) inhibits the tumor growth in vivo^[3]. K-7174 (50 mg/kg; p.o. once daily for 14 days) inhibits the tumor growth in vivo and shows a better effect than intraperitoneal injection^[3].

Animal Model:	ICR mice with IL-β or TNF-α injection^[2]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection; 30 mg/kg once daily for 9 days
Result:	Increased erythropoietin (Epo) production, reticulocyte counts, and hemoglobin (Hb) concentrations

Animal Model:	NOD/SCID mice with murine xenograft^[3]
Dosage:	75 mg/kg
Administration:	Intraperitoneal injection; once daily for 14 days
Result:	Significantly decreased tumor volume, but showed a significant body weight reduction after 10 days.

Animal Model:	NOD/SCID mice with murine xenograft^[3]
Dosage:	50 mg/kg
Administration:	Oral gavage; once daily for 14 days
Result:	Showed an anti-myeloma activity. Proved oral administration is more effective than intraperitoneal injection.

References

[1] Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4. DOI:10.1006/bbrc.2000.2784
[2] Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. FASEB J. 2003 Sep;17(12):1742-4. DOI:10.1096/fj.02-1134fje
[3] Kikuchi J, et al. The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602. DOI:10.1074/jbc.M113.480574

K-7174 Preparation Products And Raw materials

Raw materials

Preparation Products

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K-7174 Suppliers

China 30 United States 4 Global 34

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7777
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Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9548
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3290
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Finetech Industry Limited

Tel: +86-27-8746-5837 +8619945049750
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9540
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
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Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1141
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
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191089-59-5, K-7174Related Search:

K7174; K 7174

K-7174

K-7174(FREE BASE)

1H-1,4-Diazepine, hexahydro-1,4-bis[(4E)-5-(3,4,5-trimethoxyphenyl)-4-penten-1-yl]-

K-7174,K 7174,inhibit,K7174,Inhibitor

1,4-Bis((E)-5-(3,4,5-trimethoxyphenyl)pent-4-en-1-yl)-1,4-diazepane , K-7174

191089-59-5