LLL12
- Product Name
- LLL12
- CAS No.
- 1260247-42-4
- Chemical Name
- LLL12
- Synonyms
- LLL12;LLL-12 (LLL12;5-Hydroxy-9,10-dioxo-9,10-dihydroanthra;5-hydroxy-9,10-dioxo-9,10-dihydroanthracene-1-sulfonamide;1-Anthracenesulfonamide, 9,10-dihydro-5-hydroxy-9,10-dioxo-
- CBNumber
- CB32731095
- Molecular Formula
- C14H9NO5S
- Formula Weight
- 303.29
- MOL File
- 1260247-42-4.mol
LLL12 Property
- Melting point:
- 179-181 °C
- Boiling point:
- 618.2±65.0 °C(Predicted)
- Density
- 1.626±0.06 g/cm3(Predicted)
- pka
- 6.46±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- L2652-01
- Product name
- LLL12
- Packaging
- 5mg
- Price
- $360
- Updated
- 2021/12/16
LLL12 Chemical Properties,Usage,Production
Description
LLL12 is a potent STAT3 inhibitor. LLL12 inhibits colony formation and cell migration and works synergistically with doxorubicin and gemcitabine. LLL12 demonstrated a potent inhibitory activity on breast and glioblastoma tumor growth in a mouse xenograft model. LLL12 may be a potential therapeutic agent for human cancer cells expressing constitutive STAT3 signaling.
Uses
LLL12 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin (HY-17394) and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth[1].
in vivo
LLL12 (5 mg/kg; i.p.; once daily for 13 d) shows strong growth inhibition activity in mouse osteosarcoma cells and tumor growth[2].
| Animal Model: | Mouse xenografts with SJSA or OS-33 osteosarcoma cells[2] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; once daily for 13 days |
| Result: | Resulted in a significant reduction in tumor volume and tumor mass in the OS-33 and SJSA xenografted mice. |
IC 50
p-STAT3
References
[1] Zhang R, et al. A small molecule STAT3 inhibitor, LLL12, enhances cisplatin? and paclitaxel?mediated inhibition of cell growth and migration in human ovarian cancer cells. Oncol Rep. 2020 Sep;44(3):1224-1232. DOI:10.3892/or.2020.7667
[2] Onimoe GI, et al. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Invest New Drugs. 2012 Jun;30(3):916-26. DOI:10.1007/s10637-011-9645-1
LLL12 Preparation Products And Raw materials
Raw materials
Preparation Products
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