ChemicalBook > CAS DataBase List > Voruciclib

Voruciclib

Product Name
Voruciclib
CAS No.
1000023-04-0
Chemical Name
Voruciclib
Synonyms
CS-2788;P1446A05;P1446A 05;P1446A-05;Voruciclib;UNII-W66XP666AM;Voruciclib (P1446A-05);Voruciclib, 10 mM in DMSO;P1446A05; P1446A-05; P1446A 05; VORUCICLIB;2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one
CBNumber
CB32731161
Molecular Formula
C22H19ClF3NO5
Formula Weight
469.84
MOL File
1000023-04-0.mol
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Voruciclib Property

Boiling point:
587.6±50.0 °C(Predicted)
Density 
1.493±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A crystalline solid
pka
6.36±0.40(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29085
Product name
Voruciclib
Packaging
1mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
29085
Product name
Voruciclib
Packaging
10mg
Price
$530
Updated
2024/03/01
Cayman Chemical
Product number
29085
Product name
Voruciclib
Packaging
5mg
Price
$289
Updated
2024/03/01
ChemScene
Product number
CS-0011273
Product name
Voruciclib
Purity
99.52%
Packaging
1mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-0011273
Product name
Voruciclib
Purity
99.52%
Packaging
5mg
Price
$550
Updated
2021/12/16
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Voruciclib Chemical Properties,Usage,Production

Uses

Voruciclib is a cyclin-dependent kinase (CDK) inhibitor. It is a derivative of Flavone (F371050) and can be used for treatment of proliferative disorders such as cancer.

in vivo

Combination of Voruciclib hydrochloride (200 mpk; Oral gavage) and Venetoclax (10 mpk, 1 mpk, 50 mpk, 25 mpk in U2932, RIVA, SU-DHL-4 and NU-DHL-1, respectively) leads to enhance tumor growth inhibition compared to either drug alone in U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), and NU-DHL-1 models (five days per week for 3 weeks) of DLBCL[1].

Animal Model:ABC subtypes (U2932, RIVA, OCI-LY10), GCB subtypes (SU-DHL-4, NU-DHL-1) xenografted in Female NOD.CB17-Prkdcscid/NCrHsd mice
Dosage:200 mpk
Administration: Oral gavage; U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), OCI-LY10 (six days per week for 2 weeks), NU-DHL-1 (five days per week for 3 weeks)
Result:Enhanced tumor growth inhibition in U2932, RIVA, SU-DHL-4 and NU-DHL-1 models except in OCI-LY10 model.

IC 50

CDK9/cyc T2: 0.626 nM (Ki); CDK9/CycT1: 1.68 nM (Ki); CDK6/cycD1: 2.92 nM (Ki); CDK4/Cyc D1: 3.96 nM (Ki); CDK1/cycB: 5.4 nM (Ki); CDK1/cyc A: 9.1 nM (Ki)

Voruciclib Preparation Products And Raw materials

Raw materials

Preparation Products

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Voruciclib Suppliers

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1000023-04-0, VoruciclibRelated Search:


  • Voruciclib
  • 2-[2-Chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-4H-1-benzopyran-4-one
  • UNII-W66XP666AM
  • 2-(2-chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one
  • CS-2788
  • P1446A 05
  • P1446A05
  • P1446A-05
  • P1446A05; P1446A-05; P1446A 05; VORUCICLIB
  • 4H-1-Benzopyran-4-one, 2-[2-chloro-4-(trifluoromethyl)phenyl]-5,7-dihydroxy-8-[(2R,3S)-2-(hydroxymethyl)-1-methyl-3-pyrrolidinyl]-
  • Voruciclib (P1446A-05)
  • Cyclin dependent kinase,CDK,B-cell,multiple,inhibit,diffuse,clinical,models,DLBCL,MCL-1,large,CDK9,Inhibitor,Voruciclib,stage,orally,lymphoma
  • Voruciclib, 10 mM in DMSO
  • 1000023-04-0
  • C22H19ClF3NO5