4-Chloro-2,6-diMethylquinazoline
- Product Name
- 4-Chloro-2,6-diMethylquinazoline
- CAS No.
- 1429782-21-7
- Chemical Name
- 4-Chloro-2,6-diMethylquinazoline
- Synonyms
- 4-Chloro-2,6-diMethylquinazoline;Quinazoline, 4-chloro-2,6-dimethyl-
- CBNumber
- CB32732229
- Molecular Formula
- C10H9ClN2
- Formula Weight
- 192.64
- MOL File
- 1429782-21-7.mol
4-Chloro-2,6-diMethylquinazoline Property
- Boiling point:
- 234.4±33.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.41±0.30(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2782DV
- Product name
- 4-Chloro-2,6-dimethylquinazoline
- Packaging
- 25g
- Price
- $2791
- Updated
- 2021/12/16
- Product number
- A101655
- Product name
- 4-Chloro-2,6-dimethylquinazoline
- Purity
- 95%
- Packaging
- 100mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- A101655
- Product name
- 4-Chloro-2,6-dimethylquinazoline
- Purity
- 95%
- Packaging
- 250mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- A101655
- Product name
- 4-Chloro-2,6-dimethylquinazoline
- Purity
- 95%
- Packaging
- 1g
- Price
- $156
- Updated
- 2021/12/16
- Product number
- CM142411
- Product name
- 4-chloro-2,6-dimethylquinazoline
- Purity
- 95%
- Packaging
- 1g
- Price
- $499
- Updated
- 2021/12/16
4-Chloro-2,6-diMethylquinazoline Chemical Properties,Usage,Production
Synthesis
18731-19-6
1429782-21-7
General procedure for the synthesis of 4-chloro-2,6-dimethylquinazolines from 2,6-dimethylquinazolin-4(1H)-ones: 1. Synthesis of 4-chloro-6-methyl-2-methylquinazoline: 2,6-dimethylquinazolin-4(1H)-one (5 g, 32 mmol) was dissolved in acetic anhydride (25 mL) and heated at reflux for 12 hours. After completion of the reaction, the mixture was concentrated to give a solid. The solid was dissolved in a mixture of ethanol (50 mL) and ammonia (50 mL) and stirred at 80 °C for 5 hours. The progress of the reaction was monitored by TLC (Spreader: EtOAc/PE = 1:1) and after confirming the consumption of raw materials and the appearance of new spots, the reaction mixture was cooled to room temperature, filtered and the filter cake was collected to afford 4-chloro-6-methyl-2-methyl quinazoline (3.5 g, yield: 60.9%). 2. Synthesis of 4-chloro-2,6-dimethylquinazoline: 4-chloro-6-methyl-2-methylquinazoline (7 g, 40 mmol) was dissolved in toluene (70 mL), N,N-diisopropylethylamine (DIPEA, 10.3 g, 80 mmol) and phosphorus oxychloride (POCl3, 10.4 g, 64 mmol) were added. The mixture was stirred at 80 °C for 4 hours. The progress of the reaction was monitored by TLC (unfolding agent: PE/EtOAc = 3:1) and after confirming the consumption of raw materials and the appearance of new spots, the reaction mixture was concentrated. The crude product was purified by silica gel column chromatography (eluent: PE/EtOAc = 20:1) to afford the target compound 4-chloro-2,6-dimethylquinazoline (5 g, yield: 64.7%) as a white solid. 1H NMR (CDCl3, 400 MHz): δ = 7.94 (s, 1H), 7.84 (d, J = 8.8 Hz, 1H), 7.72 (m, J = 10.8 Hz, 1H), 2.81 (s, 3H), 2.55 (s, 3H).
References
[1] Patent: WO2013/50527, 2013, A1. Location in patent: Page/Page column 58; 59
4-Chloro-2,6-diMethylquinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
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