5-BroMo-1,3-diMethyl-1H-indole
- Product Name
- 5-BroMo-1,3-diMethyl-1H-indole
- CAS No.
- 10075-49-7
- Chemical Name
- 5-BroMo-1,3-diMethyl-1H-indole
- Synonyms
- 5-bromo-1,3-dimethylindole;5-BroMo-1,3-diMethyl-1H-indole;1H-Indole, 5-bromo-1,3-dimethyl-
- CBNumber
- CB32732395
- Molecular Formula
- C10H10BrN
- Formula Weight
- 224.1
- MOL File
- 10075-49-7.mol
5-BroMo-1,3-diMethyl-1H-indole Property
- Boiling point:
- 317.5±22.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 1164CY
- Product name
- 5-Bromo-1,3-dimethyl-1H-indole
- Packaging
- 1g
- Price
- $1083
- Updated
- 2021/12/16
- Product number
- 1164CY
- Product name
- 5-Bromo-1,3-dimethyl-1H-indole
- Packaging
- 5g
- Price
- $3260
- Updated
- 2021/12/16
- Product number
- CM148120
- Product name
- 5-bromo-1,3-dimethyl-1H-indole
- Purity
- 95%+
- Packaging
- 5g
- Price
- $2062
- Updated
- 2021/12/16
- Product number
- 10075497
- Product name
- 5-Bromo-1,3-dimethyl-1H-indole
- Packaging
- 5g
- Price
- $2227.05
- Updated
- 2021/12/16
- Product number
- A167400
- Product name
- 5-Bromo-1,3-dimethyl-1H-indole
- Purity
- 97%
- Packaging
- 50mg
- Price
- $142
- Updated
- 2021/12/16
5-BroMo-1,3-diMethyl-1H-indole Chemical Properties,Usage,Production
Synthesis
10075-48-6
75-03-6
10075-49-7
5-Bromo-1,3-dimethyl-1H-indole was synthesized as follows: according to the methods reported in the literature (Fraile, J. M.; Le Jeune, K.; Mayoral, J. A.; Ravasio, N.; Zaccheria, F.; Org. Biomol. Chem. 2013, 11, 4327-4332) Perform the preparation. 5-Bromo-3-methyl-1H-indole (0.30 g, 1.437 mmol, 1.00 equiv) was dissolved in anhydrous THF (5.0 mL) and cooled to 0-5 °C. NaH (60% dispersed in mineral oil, 0.14 g, 2.86 mmol, 2.00 eq.) was added in batches over 10 min. The reaction mixture (RM) was stirred at 0 °C for 1 h. Ethyl iodide (0.21 mL, 2.86 mmol, 2.0 eq.) was added dropwise. Subsequently, the reaction mixture was continued to be stirred at 0 °C for 30 min and then at room temperature for 18 h. The reaction mixture was then stirred for 1 h at room temperature. After completion of the reaction, the reaction mixture was poured into ice water and extracted with ether. The organic layer was washed with brine and dried over Na2SO4. Finally, the solvent was removed by vacuum evaporation to afford the target product 5-bromo-1,3-dimethyl-1H-indole (0.355 g, 1.33 mmol, 93.2% yield; 84% UPLC yield) as a light yellow oil.
References
[1] Patent: WO2016/180536, 2016, A1. Location in patent: Page/Page column 292
5-BroMo-1,3-diMethyl-1H-indole Preparation Products And Raw materials
Raw materials
Preparation Products
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