UNC0379 (trifluoroacetate)
- Product Name
- UNC0379 (trifluoroacetate)
- CAS No.
- 1620401-83-3
- Chemical Name
- UNC0379 (trifluoroacetate)
- Synonyms
- UNC0379 TFA;UNC0379 (trifluoroacetate);UNC0379 trifluoroacetate salt;UNC0379 trifluoroacetate salt >=98% (HPLC)
- CBNumber
- CB32735543
- Molecular Formula
- C25H36F3N5O4
- Formula Weight
- 527.59
- MOL File
- 1620401-83-3.mol
UNC0379 (trifluoroacetate) Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Light yellow to khaki
- Water Solubility
- H2O: 5mg/mL, clear
N-Bromosuccinimide Price
- Product number
- CS-3606
- Product name
- UNC0379TFA
- Purity
- 99.91%
- Packaging
- 2mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-3606
- Product name
- UNC0379TFA
- Purity
- 99.91%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- orb611655
- Product name
- UNC0379 trifluoroacetate
- Packaging
- 100mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- orb611655
- Product name
- UNC0379 trifluoroacetate
- Packaging
- 250mg
- Price
- $1504.5
- Updated
- 2021/12/16
- Product number
- DC23217
- Product name
- UNC0379trifluoroacetate
- Purity
- >98%
- Packaging
- 1g
- Price
- $2000
- Updated
- 2021/12/16
UNC0379 (trifluoroacetate) Chemical Properties,Usage,Production
Biological Activity
SETD8 expression is observed in cancers such as bladder cancer, chronic myelogenous leukemia, hepatocellular carcinoma, non‐small‐cell lung carcinoma, prostate cancer, small‐cell lung carcinoma. Therefore inhibition of SETD8 (SET‐domain containing protein) by UNC0379 might prevent the progression of cancer.', 'UNC0379 is the first substrate-competitive inhibitor of the lysine methyltransferase SETD8, the only known methyltransferase th at catalyzes monomethylation of histone H4 lysine 20 (H4K20). HK420 methylation has been implicated in the regulation of a variety of biological processes including the DNA damage response. UNC0379 is selective for SETD8 over 15 other methyltransferases, with an IC50 value of 7.3 μM for SETD8 compared to IC50 vlaues over 100 μM for other methyltransferases.
UNC0379 (trifluoroacetate) Preparation Products And Raw materials
Raw materials
Preparation Products
UNC0379 (trifluoroacetate) Suppliers
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
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- United States
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- tp@aladdinsci.com
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- United States
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- 16314854226
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- United States
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- sales@medchemexpress.com
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- United States
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