2-fluoro-4-iodo-5-(MethoxyMethoxy)pyridine
- Product Name
- 2-fluoro-4-iodo-5-(MethoxyMethoxy)pyridine
- CAS No.
- 1034467-27-0
- Chemical Name
- 2-fluoro-4-iodo-5-(MethoxyMethoxy)pyridine
- Synonyms
- uoro-4-iodo-5-(methoxymethoxy)pyridine;2-fluoro-4-iodo-5-(MethoxyMethoxy)pyridine;Pyridine, 2-fluoro-4-iodo-5-(methoxymethoxy)-;2-fluoro-4-iodo-5-(methoxymethoxy)pyridine - [F81175]
- CBNumber
- CB32736146
- Molecular Formula
- C7H7FINO2
- Formula Weight
- 283.04
- MOL File
- 1034467-27-0.mol
2-fluoro-4-iodo-5-(MethoxyMethoxy)pyridine Property
- storage temp.
- 2-8°C(protect from light)
- form
- powder
- color
- Off-white
- InChI
- InChI=1S/C7H7FINO2/c1-11-4-12-6-3-10-7(8)2-5(6)9/h2-3H,4H2,1H3
- InChIKey
- DPHOQZPEXMFCGW-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=C(OCOC)C(I)=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F632568
- Product name
- 2-Fluoro-4-iodo-5-(methoxymethoxy)pyridine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC48727
- Product name
- 2-Fluoro-4-iodo-5-(methoxymethoxy)pyridine
- Packaging
- 500mg
- Price
- $172
- Updated
- 2021/12/16
- Product number
- 188228
- Product name
- 2-Fluoro-4-iodo-5-(methoxymethoxy)pyridine
- Packaging
- 1g
- Price
- $293
- Updated
- 2021/12/16
- Product number
- PC48727
- Product name
- 2-Fluoro-4-iodo-5-(methoxymethoxy)pyridine
- Packaging
- 1g
- Price
- $308
- Updated
- 2021/12/16
- Product number
- 4H56-K-05
- Product name
- 2-Fluoro-4-iodo-5-(methoxymethoxy)pyridine
- Packaging
- 500mg
- Price
- $312
- Updated
- 2021/12/16
2-fluoro-4-iodo-5-(MethoxyMethoxy)pyridine Chemical Properties,Usage,Production
Synthesis
1034467-25-8
1034467-27-0
General procedure for the synthesis of 2-fluoro-4-iodo-5-(methoxymethoxy)pyridine from 2-fluoro-5-(methoxymethoxy)pyridine: 2-fluoro-5-(methoxymethoxy)pyridine (4.1 g, 26.1 mmol) was dissolved in THF (60 mL) and cooled to -75 °C. Tert-butyl lithium (1.7 M in pentane, 30.4 mL, 51.7 mmol) was slowly added over 30 min. After addition, stirring was continued at -75 °C for 30 min. Subsequently, iodine (9.8 g, 38.6 mmol, dissolved in 60 mL THF) was added. After addition, stirring was continued for 1 hour. The temperature was slowly increased to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched with water. The reaction mixture was extracted with ethyl acetate (3 × 60 mL). The organic layers were combined and washed with saturated aqueous sodium chloride. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a brown solid. The brown solid was ground with hexane and filtered to give 2-fluoro-4-iodo-5-(methoxymethoxy)pyridine (3.9 g, 53% yield) as a brown solid.1H NMR (400 MHz, CDCl3) δ 3.53 (s, 3H), 5.23 (s, 2H), 7.39 (d, J = 4.0 Hz, 1H), 7.96 (d, J = 1.6 Hz, 1H).
References
[1] Patent: WO2008/144222, 2008, A2. Location in patent: Page/Page column 19-20
[2] Patent: WO2008/76705, 2008, A1. Location in patent: Page/Page column 10
2-fluoro-4-iodo-5-(MethoxyMethoxy)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-fluoro-4-iodo-5-(MethoxyMethoxy)pyridine Suppliers
- Tel
- 010-60400365-8001 15910885229
- Fax
- 010-60400361
- service@bellenchem.com
- Country
- China
- ProdList
- 4514
- Advantage
- 60
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 025-58362220 0086-15250997978
- Fax
- 025-58362220
- sale@njxizebio.com
- Country
- China
- ProdList
- 4855
- Advantage
- 55
- Tel
- 025-66800956 18800000000
- Fax
- qq3325708371
- sales@njdmchem.com
- Country
- China
- ProdList
- 4200
- Advantage
- 50
- Tel
- 0086-15313090952
- Fax
- 0086-010-80236392
- Country
- China
- ProdList
- 2355
- Advantage
- 58
- Tel
- 025-66113011 13155353615
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15394
- Advantage
- 58
- Tel
- 0512-6956-1983
- info@xenoah.com
- Country
- China
- ProdList
- 296
- Advantage
- 58
- Tel
- 0512-69561983 13914027025
- Fax
- 0512-69561982
- zhang_q@medinoah.com
- Country
- China
- ProdList
- 3811
- Advantage
- 58
- Tel
- 028-84641798 18782128315
- 3302391190@qq.com
- Country
- China
- ProdList
- 9799
- Advantage
- 55