VRT-1353385

Product Name: VRT-1353385
CAS No.: 1616113-45-1
Chemical Name: VRT-1353385
Synonyms: EB8018;CS-1707;Sibofimloc;VRT-1353385;Antibiotic-202;VRT 1353385;VRT1353385;Sibofimloc, 10 mM in DMSO;Antibiotic 202, Sibofimloc;Antibiotic-202, VRT-1353385;Sibofimloc (VRT-1353385, Antibiotic-202)
CBNumber: CB32741568
Molecular Formula: C35H39NO11
Formula Weight: 649.68
MOL File: 1616113-45-1.mol

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VRT-1353385 Property

storage temp.: Store at -20°C
solubility: ≥ 20.2mg/mL in DMSO
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5487
Product name: Sibofimloc
Purity: 98.62%
Packaging: 5mg
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-5487
Product name: Sibofimloc
Purity: 98.62%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5487
Product name: Sibofimloc
Purity: 98.62%
Packaging: 50mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-5487
Product name: Sibofimloc
Purity: 98.62%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: DC8047
Product name: VRT-1353385
Purity: >98%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

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VRT-1353385 Chemical Properties,Usage,Production

Uses

Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD)[1][2].

References

[1] Ramtohul, Yeeman K, et al. Preparation of mannose derivatives via coupling and click cycloaddition reactions for treating bacterial infections. From PCT Int. Appl. (2014), WO 2014100158 A1 20140626.
[2] W Reinisch, et al. P568 An open-label, multicenter, phase ib, pharmacokinetic (pk) and safety study of a fimh blocker, Sibofimloc (TAK-018/EB8018), in patients with Crohn’s disease (CD), Journal of Crohn's and Colitis, Volume 14, Issue Supplement_1, January 2020: S479–S480.

VRT-1353385 Preparation Products And Raw materials

Raw materials

Preparation Products

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VRT-1353385 Suppliers

China 51 United States 7 Global 58

Shanghai Boyle Chemical Co., Ltd.

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Beijing Jin Ming Biotechnology Co., Ltd.

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1616113-45-1, VRT-1353385Related Search:

1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone

VRT 1353385;VRT1353385

1-(2,7-bis(((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)ethynyl)-1'l4-spiro[fluorene-9,4'-piperidin]-1'-yl)ethan-1-one

Antibiotic-202, VRT-1353385

CS-1707

Sibofimloc

VRT-1353385

Antibiotic-202

8,8'-(1'-Acetylspiro[9H-fluorene-9,4'-piperidine]-2,7-diyl)bis[2,6-anhydro-7,8-dideoxy-D-glycero-D-manno-oct-7-ynitol]

1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone

Antibiotic 202, Sibofimloc

D-glycero-D-manno-Oct-7-ynitol, 8,8'-(1'-acetylspiro[9H-fluorene-9,4'-piperidine]-2,7-diyl)bis[2,6-anhydro-7,8-dideoxy-

EB8018

disease,Sibofimloc,Crohn's,bowel,Antibiotic202,Bacterial,IBD,inhibit,colitis,inflammatory,Antibiotic,Inhibitor,ulcerative

1-(2,7-Bis(((2R,3S,4R,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)ethynyl)spiro[fluorene-9,4'-piperidin]-1'-yl)ethan-1-one

Sibofimloc, 10 mM in DMSO

Sibofimloc (VRT-1353385, Antibiotic-202)

1-(2,7-Bis(((2R,3S,4R,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)ethynyl)spiro[fluorene-9,4'-piperidin]-1'-yl)ethan-1-one

1616113-45-1

C35H39NO11