Gambogenic acid

Product Name: Gambogenic acid
CAS No.: 173932-75-7
Chemical Name: Gambogenic acid
Synonyms: Gambogenic acid;Gambogenic acid, 10 mM in DMSO;Gambogenic acid,Histone Methyltransferase,inhibit,Inhibitor;(Z)-4-((1R,3aS,5S,12aS)-9-((E)-3,7-Dimethylocta-2,6-dien-1-yl)-8,10-dihydroxy-2,2-dimethyl-11-(3-methylbut-2-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-1,5-methanofuro[2,3-d]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid;(2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid;2-Butenoic acid, 4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-, (2Z)-
CBNumber: CB32743193
Molecular Formula: C38H46O8
Formula Weight: 630.78
MOL File: 173932-75-7.mol

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Gambogenic acid Property

Boiling point:: 818.6±65.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (396.34 mM; Need ultrasonic)
form: Powder
pka: 4.58±0.36(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0032096
Product name: Gambogenicacid
Purity: 99.91%
Packaging: 5mg
Price: $269
Updated: 2021/12/16

ChemScene

Product number: CS-0032096
Product name: Gambogenicacid
Purity: 99.91%
Packaging: 10mg
Price: $457
Updated: 2021/12/16

Arctom

Product number: CFN92097
Product name: Gambogenicacid
Packaging: 10mg
Price: $358
Updated: 2021/12/16

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Gambogenic acid Chemical Properties,Usage,Production

Chemical Properties

Brown-red crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Garcinia.

Uses

Gambogenic acid is an active ingredient that can be isolated from gamboge. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Gambogenic acid can be used for the research of cancer[1][2].

in vivo

Gambogenic acid (4-12 mg/kg, i.v., every 2 days, 14 days) inhibits tumor growth in SCLC mouse xenograft model^[2].

Animal Model:	SCLC mouse xenograft model^[1]
Dosage:	4-12 mg/kg
Administration:	i.v., every 2 days, 14 days
Result:	Increased the expression of pro-apoptotic proteins (cleaved caspase-3, -8 and -9, Bax, cleaved PARP and p53 proteins). Decreased the anti-apoptotic proteins (Bcl-2).

IC 50

EZH2

References

[1] Wang X, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260. DOI:10.15252/embj.201694058
[2] Huang T, et al. Gambogenic acid inhibits the proliferation of small?cell lung cancer cells by arresting the cell cycle and inducing apoptosis. Oncol Rep. 2019 Mar;41(3):1700-1706. DOI:10.3892/or.2018.6950

Gambogenic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Gambogenic acid Suppliers

China 103 United States 7 Global 110

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
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Chengdu Biopurify Phytochemicals Ltd.

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Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
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Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
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Email: sales@reading-chemicals.com
Country: China
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Nanjing Endesa Bio-tech Co., Ltd.

Tel: 025-58862853 18915922038
Fax: +86-025-58862853
Email: sales@endesachem.com
Country: China
ProdList: 591
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Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
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EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
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Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
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Shanghai YuanYe Biotechnology Co., Ltd.

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Fax: QQ:3008007432
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Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
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Email: shcss01@163.com
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
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View Lastest Price from Gambogenic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Gambogenic acid 173932-75-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Gambogenic acid 173932-75-7
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-06-04

Hebei Yanxi Chemical Co., Ltd.

Product: Gambogenic acid 173932-75-7
Price: US $60.00-16.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-14

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Gambogenic acid

(2Z)-4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-2-butenoic acid

2-Butenoic acid, 4-[(1R,3aS,5S,12aS)-9-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-3a,4,5,7-tetrahydro-8,10-dihydroxy-3,3-dimethyl-11-(3-methyl-2-buten-1-yl)-7,13-dioxo-1,5-methano-1H,3H-furo[3,4-d]xanthen-1-yl]-2-methyl-, (2Z)-

Gambogenic acid,Histone Methyltransferase,inhibit,Inhibitor

(Z)-4-((1R,3aS,5S,12aS)-9-((E)-3,7-Dimethylocta-2,6-dien-1-yl)-8,10-dihydroxy-2,2-dimethyl-11-(3-methylbut-2-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-1,5-methanofuro[2,3-d]xanthen-3a(4H)-yl)-2-methylbut-2-enoic acid

Gambogenic acid, 10 mM in DMSO

173932-75-7

C38H46O8