ChemicalBook > CAS DataBase List > N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3

N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3

Product Name
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3
CAS No.
193611-67-5
Chemical Name
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3
Synonyms
SB 216641A;SB 216641 hydrochloride, h5-HT1B antagonist;N-(3-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride;N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3
CBNumber
CB32745238
Molecular Formula
C28H31ClN4O4
Formula Weight
523.03
MOL File
193611-67-5.mol
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N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Property

storage temp. 
Store at RT
solubility 
DMSO: soluble; Water: soluble
form 
Powder
color 
White to off-white
Water Solubility 
Soluble to 50 mM in water
InChIKey
JPBMDMNORXKGHZ-UHFFFAOYSA-N
SMILES
CC1C=C(C2=NOC(C)=N2)C=CC=1C1C=CC(C(=O)NC2C=CC(OC)=C(OCCN(C)C)C=2)=CC=1.Cl
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
S155030
Product name
SB216641Hydrochloride
Packaging
50mg
Price
$685
Updated
2021/12/16
TRC
Product number
S155030
Product name
SB216641Hydrochloride
Packaging
100mg
Price
$1260
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000794
Product name
SB 216641 HYDROCHLORIDE
Purity
95.00%
Packaging
50MG
Price
$1417.71
Updated
2021/12/16
ApexBio Technology
Product number
B6653
Product name
SB216641hydrochloride
Packaging
50mg
Price
$1456
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0000794
Product name
SB 216641 HYDROCHLORIDE
Purity
95.00%
Packaging
10MG
Price
$305.55
Updated
2021/12/16
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N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Chemical Properties,Usage,Production

Uses

SB 216641 Hydrochloride is a selective SR-1B and 5-HT1B antagonist.

in vivo

SB-216641A (0.6-20 mg/kg; i.p.; single dose) hinders the SKF-99101H induced hypothermia with dose-dependent manner in guinea pigs[1].
SB-216641A (559 nmol/kg; i.v.; single dose) improves the gastric relaxation observed after injection of 800 nmol/kg Sumatriptan (HY-B0121B) in dogs when combined with 5-HT1B/D receptor antagonist GR-127935[2].

Animal Model:Guinea pigs[1].
Dosage:0.6, 2.0, 6.0 and 20.0 mg/kg.
Administration:Intraperitoneal injection; single dose.
Result:Significantly blocked the effects of SKF-99101H.
Animal Model:Dogs[2].
Dosage:559 nmol/kg.
Administration:Intravenous injection; single dose.
Result:Improved the gastric relaxation.

IC 50

5-HT1B Receptor; 5-HT1D Receptor

storage

Store at RT

N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 Suppliers

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193611-67-5, N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3Related Search:


  • N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3
  • SB 216641A
  • SB 216641 hydrochloride, h5-HT1B antagonist
  • N-(3-(2-(dimethylamino)ethoxy)-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride
  • 193611-67-5