N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

Product Name: N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine
CAS No.: 1507370-20-8
Chemical Name: N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine
Synonyms: BC-1215;BC-1215 ，S0322;BC-1215 (BC 1215;BC-1215 >=98% (HPLC);BC-1215, 10 mM in DMSO;Fbxo3 Inhibitor, BC-1215;N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine;N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine;1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-;{[4-(pyridin-2-yl)phenyl]methyl}[2-({[4-(pyridin-2-yl)phenyl]methyl}amino)ethyl]amine
CBNumber: CB32750524
Molecular Formula: C26H26N4
Formula Weight: 394.51
MOL File: 1507370-20-8.mol

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N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Property

Boiling point:: 589.9±50.0 °C(Predicted)
Density: 1.125±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: soluble2mg/mL, clear (warmed)
pka: 9.05±0.20(Predicted)
form: A crystalline solid
color: white to beige
InChI: InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
InChIKey: IXEPQJQQSLMESJ-UHFFFAOYSA-N
SMILES: C(NCC1=CC=C(C2=NC=CC=C2)C=C1)CNCC1=CC=C(C2=NC=CC=C2)C=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21964
Product name: BC-1215
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 21964
Product name: BC-1215
Purity: ≥98%
Packaging: 5mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 21964
Product name: BC-1215
Purity: ≥98%
Packaging: 10mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 21964
Product name: BC-1215
Purity: ≥98%
Packaging: 25mg
Price: $486
Updated: 2024/03/01

AK Scientific

Product number: 0448DW
Product name: N,N'-Bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine
Packaging: 25mg
Price: $606
Updated: 2021/12/16

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N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Chemical Properties,Usage,Production

Description

BC-1215 (N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine) is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). It decreases FBXO3 interaction with F-box/LRR-repeat protein 2 (FBXL2) in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2. It also lowers expression of Tnf receptor-associated factors (TRAFs) 1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated peripheral blood mononuclear cells (PBMCs). BC-1215 (100 μg, i.p., per animal) reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema.

Uses

BC-1215 is a F-box protein 3 (Fbxo3) inhibitor. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 can be used for the research of inflammation[1].

in vivo

BC-1215 (i.p.; 100 μg) reduces bacterial-induced inflammationa^[1].

Animal Model:	Cecal ligation and puncture (CLP)-induced sepsis model^[1]
Dosage:	100 μg
Administration:	i.p.
Result:	Significantly attenuated CLP-induced secretion of all three circulating pro-inflammatory cytokines and decreased bacterial counts in the CLP model.

IC 50

Fbxo3

References

[1] Chen BB, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulateinflammation. Nat Immunol. 2013 May;14(5):470-9. DOI:10.1038/ni.2565

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Suppliers

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1507370-20-8, N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamineRelated Search:

BC-1215

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

BC-1215 (BC 1215

1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-

BC-1215 >=98% (HPLC)

{[4-(pyridin-2-yl)phenyl]methyl}[2-({[4-(pyridin-2-yl)phenyl]methyl}amino)ethyl]amine

N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine

Ligands for E3 Ligase,E3 ligase-recruiting Moiety,F-box protein 3 (Fbxo3),Inhibitor,inhibit,inflammation,MLE cells,BC 1215,PBMC cells,BC-1215,BC1215,U937 cells,TRAF

BC-1215, 10 mM in DMSO

Fbxo3 Inhibitor, BC-1215

BC-1215 ，S0322

1507370-20-8