ChemicalBook > CAS DataBase List > N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine

Product Name
N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine
CAS No.
1507370-20-8
Chemical Name
N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine
Synonyms
BC-1215;BC-1215 (BC 1215;BC-1215 >=98% (HPLC);N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine;N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine;1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-;{[4-(pyridin-2-yl)phenyl]methyl}[2-({[4-(pyridin-2-yl)phenyl]methyl}amino)ethyl]amine;Ligands for E3 Ligase,E3 ligase-recruiting Moiety,F-box protein 3 (Fbxo3),Inhibitor,inhibit,inflammation,MLE cells,BC 1215,PBMC cells,BC-1215,BC1215,U937 cells,TRAF
CBNumber
CB32750524
Molecular Formula
C26H26N4
Formula Weight
394.51
MOL File
1507370-20-8.mol
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N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Property

Boiling point:
589.9±50.0 °C(Predicted)
Density 
1.125±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: soluble2mg/mL, clear (warmed)
pka
9.05±0.20(Predicted)
form 
A crystalline solid
color 
white to beige
InChI
InChI=1S/C26H26N4/c1-3-15-29-25(5-1)23-11-7-21(8-12-23)19-27-17-18-28-20-22-9-13-24(14-10-22)26-6-2-4-16-30-26/h1-16,27-28H,17-20H2
InChIKey
IXEPQJQQSLMESJ-UHFFFAOYSA-N
SMILES
C(NCC1=CC=C(C2=NC=CC=C2)C=C1)CNCC1=CC=C(C2=NC=CC=C2)C=C1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21964
Product name
BC-1215
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
21964
Product name
BC-1215
Purity
≥98%
Packaging
5mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
21964
Product name
BC-1215
Purity
≥98%
Packaging
10mg
Price
$216
Updated
2024/03/01
Cayman Chemical
Product number
21964
Product name
BC-1215
Purity
≥98%
Packaging
25mg
Price
$486
Updated
2024/03/01
AK Scientific
Product number
0448DW
Product name
N,N'-Bis[(4-pyridin-2-ylphenyl)methyl]ethane-1,2-diamine
Packaging
25mg
Price
$606
Updated
2021/12/16
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N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Chemical Properties,Usage,Production

Description

BC-1215 (N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine) is an inhibitor of F-box protein 3 (FBXO3; IC50 = 0.9 μg/mL for Il-1β release). It decreases FBXO3 interaction with F-box/LRR-repeat protein 2 (FBXL2) in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2. It also lowers expression of Tnf receptor-associated factors (TRAFs) 1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated peripheral blood mononuclear cells (PBMCs). BC-1215 (100 μg, i.p., per animal) reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis. It also reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema.

N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1507370-20-8, N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamineRelated Search:


  • BC-1215
  • N1,N2-Bis[[4-(2-pyridinyl)phenyl]methyl]- 1,2-ethanediamine
  • BC-1215 (BC 1215
  • 1,2-Ethanediamine, N1,N2-bis[[4-(2-pyridinyl)phenyl]methyl]-
  • BC-1215 >=98% (HPLC)
  • {[4-(pyridin-2-yl)phenyl]methyl}[2-({[4-(pyridin-2-yl)phenyl]methyl}amino)ethyl]amine
  • N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine
  • Ligands for E3 Ligase,E3 ligase-recruiting Moiety,F-box protein 3 (Fbxo3),Inhibitor,inhibit,inflammation,MLE cells,BC 1215,PBMC cells,BC-1215,BC1215,U937 cells,TRAF
  • 1507370-20-8