ChemicalBook > CAS DataBase List > 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide

3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide

Product Name
3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
CAS No.
942655-44-9
Chemical Name
3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
Synonyms
JK-P3;JK-P3, 10 mM in DMSO;3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide;Benzamide, 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-;JK-P3,Inhibitor,HUVEC,Anti-angiogenesis,FGFR,VEGFR,JK P3,Fibroblast growth factor receptor,JKP3,Anti-cancer,inhibit,Endothelial cells,JK-P-3,Vascular endothelial growth factor receptor
CBNumber
CB32750670
Molecular Formula
C18H17N3O3
Formula Weight
323.35
MOL File
942655-44-9.mol
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3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide Property

storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL (clear solution)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
HS Code 
2933.19.4300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0509
Product name
JK-P3
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2022/05/15
TCI Chemical
Product number
J0012
Product name
JK-P3
Packaging
5MG
Price
$82
Updated
2026/03/19
TCI Chemical
Product number
J0012
Product name
JK-P3
Packaging
25MG
Price
$268
Updated
2026/03/19
Chem-Impex
Product number
42183
Product name
JK-P3,98%(HPLC)
Purity
98%(HPLC)
Packaging
5MG
Price
$131.04
Updated
2021/12/16
AK Scientific
Product number
6471DD
Product name
3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide
Packaging
5mg
Price
$220
Updated
2021/12/16
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3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide Chemical Properties,Usage,Production

Uses

JK-P3 is a potent and pan VEGFR2 inhibitor, with IC50s of 7.83 μM, 27 μM and 5.18 μM for VEGFR2, FGFR1 and FGFR3, respectively. JK-P3 can inhibit VEGF-A-stimulated VEGFR2 activation and intracellular signalling, also inhibits endothelial monolayer wound closure and angiogenesis, as well as fibroblast growth factor receptor kinase activity in vitro. JK-P3 has anti-angiogenic activity[1].

IC 50

VEGFR2: 7.83 μM (IC50); FGFR1: 27 μM (IC50); FGFR3: 5.18 μM (IC50)

References

[1] Kankanala J, et al. A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis. Br J Pharmacol. 2012;166(2):737-748. DOI:10.1111/j.1476-5381.2011.01801.x

3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide Suppliers

Americas 1 China 53 Europe 1 India 1 Japan 1 United States 6 Global 63
Shanghai Boyle Chemical Co., Ltd.
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Fax
86-21-57758967
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sales@boylechem.com
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China
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
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TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
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TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
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Americas
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Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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sales@shjiyipharmatech.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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Medi-tech Bioscientific Co., Ltd.
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0519-83246372 13585352506
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0519-83246372
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China
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942655-44-9, 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamideRelated Search:


  • 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide
  • JK-P3
  • Benzamide, 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-
  • JK-P3,Inhibitor,HUVEC,Anti-angiogenesis,FGFR,VEGFR,JK P3,Fibroblast growth factor receptor,JKP3,Anti-cancer,inhibit,Endothelial cells,JK-P-3,Vascular endothelial growth factor receptor
  • JK-P3, 10 mM in DMSO
  • 942655-44-9