Pre-queuosine1 dihydrochloride

Product Name: Pre-queuosine1 dihydrochloride
CAS No.: 86694-45-3
Chemical Name: Pre-queuosine1 dihydrochloride
Synonyms: PreQ1;preQ1 2HCl;PreQ1 dihydrochloride;Pre-queuosine1 dihydrochloride;PreQ1 dihydrochloride >=98% (HPLC);7-Aminomethyl-7-deazaguanine dihydrochloride;2-Amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4(3H)-one;Preq1 Dihydrochloride,Preq1Dihydrochloride,Preq-1-Dihydrochloride;2-Amino-5-(aminomethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one dihydrochloride;4H-Pyrrolo[2,3-d]pyrimidin-4-one,2-amino-5-(aminomethyl)-1,7-dihydro-, dihydrochloride
CBNumber: CB32750690
Molecular Formula: C7H11Cl2N5O
Formula Weight: 252.10114
MOL File: 86694-45-3.mol

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Pre-queuosine1 dihydrochloride Property

storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
form: powder
color: white to light brown

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0807
Product name: PreQ1 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0807
Product name: PreQ1 dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $478
Updated: 2024/03/01

Cayman Chemical

Product number: 21864
Product name: preQ1 (hydrochloride)
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 21864
Product name: preQ1 (hydrochloride)
Packaging: 25mg
Price: $404
Updated: 2024/03/01

Cayman Chemical

Product number: 21864
Product name: preQ1 (hydrochloride)
Packaging: 1mg
Price: $48
Updated: 2024/03/01

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Pre-queuosine1 dihydrochloride Chemical Properties,Usage,Production

Uses

preQ1 dihydrochloride is a modified, guanine-derived nucleobase and a precursor of Queuine.html" class="link-product" target="_blank">Queuine (HY-N10574) biosynthesis. preQ1 dihydrochloride binds to the aptamer of PreQ1 riboswitch with high affinity[1].

Biochem/physiol Actions

PreQ1 (pre-queuosine1) is an intermediate of the queuosine pathway. Also, PreQ1 binds with high affinity to the aptamer of PreQ1 riboswitch, which attenuates protein expression.

References

[1] Connelly CM, et al. Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat Commun. 2019 Apr 2;10(1):1501. DOI:10.1038/s41467-019-09493-3

Pre-queuosine1 dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Pre-queuosine1 dihydrochloride Suppliers

China 35 United Kingdom 1 United States 4 Global 40

Sigma-Aldrich

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Novachemistry

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DC Chemicals

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86694-45-3, Pre-queuosine1 dihydrochlorideRelated Search:

2-Amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4(3H)-one

2-Amino-5-(aminomethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one dihydrochloride

7-Aminomethyl-7-deazaguanine dihydrochloride

PreQ1 dihydrochloride

Pre-queuosine1 dihydrochloride

preQ1 2HCl

PreQ1

PreQ1 dihydrochloride >=98% (HPLC)

Preq1 Dihydrochloride,Preq1Dihydrochloride,Preq-1-Dihydrochloride

4H-Pyrrolo[2,3-d]pyrimidin-4-one,2-amino-5-(aminomethyl)-1,7-dihydro-, dihydrochloride

86694-45-3