ChemicalBook > CAS DataBase List > NSC 600157

NSC 600157

Product Name
NSC 600157
CAS No.
31083-55-3
Chemical Name
NSC 600157
Synonyms
PRT4165;NSC 600157;PRT 4165(NSC 600157);PRT4165 >=98% (HPLC);2-(3-Pyridylmethylene)-1,3-indandione; 2-(pyridin-3-ylmethylidene)indene-1,3-dione;2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione;2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione;1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-;PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157
CBNumber
CB32750711
Molecular Formula
C15H9NO2
Formula Weight
235.24
MOL File
31083-55-3.mol
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NSC 600157 Property

Melting point:
154-161 °C(Solv: ethanol (64-17-5))
Boiling point:
377.63°C (rough estimate)
Density 
1.1757 (rough estimate)
refractive index 
1.6231 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
pka
3.24±0.12(Predicted)
form 
powder
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
RTECS 
NK6710000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1013
Product name
PRT4165
Purity
≥98% (HPLC)
Packaging
5mg
Price
$106
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1013
Product name
PRT4165
Purity
≥98% (HPLC)
Packaging
25mg
Price
$417
Updated
2024/03/01
Sigma-Aldrich
Product number
EME00468
Product name
(2E)-2-(Pyridin-3-ylmethylidene)-2,3-dihydro-1H-indene-1,3-dione
Packaging
1G
Price
$1210
Updated
2023/06/20
Cayman Chemical
Product number
19093
Product name
PRT4165
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
19093
Product name
PRT4165
Purity
≥98%
Packaging
10mg
Price
$85
Updated
2024/03/01
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NSC 600157 Chemical Properties,Usage,Production

Description

PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50?= 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1?PRT-4165 inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo?and as such represents a new tool for studying chromatin remodeling.2

Biochem/physiol Actions

PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX.

storage

Store at +4°C

References

1) Alchanati?et al. (2009),?The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2alpha cleavage complex – a potentially new drug target; PLoS One,?4?e8104 2) Ismail?et al.?(2013),?A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks; J. Biol. Chem.,?288?26944

NSC 600157 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 600157 Suppliers

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View Lastest Price from NSC 600157 manufacturers

Career Henan Chemical Co
Product
2-(pyridin-3-ylmethylidene)indene-1,3-dione 31083-55-3
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

31083-55-3, NSC 600157Related Search:

C 646 Daminozide RVX-208 5-Azacytidine 1,3-Butadiene, 2,3-dichloro-, homopolymer, brominated PRT-060318

  • PRT 4165; PRT-4165; NSC600157; NSC-600157; NSC 600157
  • 2-(pyridin-3-ylmethylidene)indene-1,3-dione
  • 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione
  • 2-(3-Pyridylmethylene)-1,3-indandione
  • NSC 600157
  • PRT4165
  • PRT 4165(NSC 600157)
  • 1H-Indene-1,3(2H)-dione, 2-(3-pyridinylmethylene)-
  • PRT4165 >=98% (HPLC)
  • 2-(Pyridin-3-ylmethylene)-1H-indene-1,3(2H)-dione
  • 31083-55-3