ChemicalBook > CAS DataBase List > 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID

2-HYDROXY-3-PYRAZINECARBOXYLIC ACID

Product Name
2-HYDROXY-3-PYRAZINECARBOXYLIC ACID
CAS No.
20737-42-2
Chemical Name
2-HYDROXY-3-PYRAZINECARBOXYLIC ACID
Synonyms
2-Carboxy-3-hydroxypyrazine;3-Hydroxypyrazine-2-carbo...;3-Hydroxypyrazinecarboxylic acid;2-oxo-1H-pyrazine-3-carboxylicaci;2-oxo-1H-pyrazine-3-carboxylic acid;3-Hydroxy-2-pyrazinecarboxylic acid;2-HYDROXY-3-PYRAZINECARBOXYLIC ACID;3-HYDROXYPYRAZINE-2-CARBOXYLIC ACID;3-hydroxy-2-piperazinecarboxylic acid;3-HYDROXY-PIPERAZINE-2-CARBOXYLIC ACID
CBNumber
CB3276916
Molecular Formula
C5H4N2O3
Formula Weight
140.1
MOL File
20737-42-2.mol
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2-HYDROXY-3-PYRAZINECARBOXYLIC ACID Property

Melting point:
218-220 °C
Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
12.72±0.20(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C5H4N2O3/c8-4-3(5(9)10)6-1-2-7-4/h1-2H,(H,7,8)(H,9,10)
InChIKey
FJZRUSFQHBBTCC-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=NC=CNC1=O
CAS DataBase Reference
20737-42-2(CAS DataBase Reference)
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E588783
Product name
3-Oxo-3,4-dihydropyrazine-2-carboxylicAcid
Packaging
250mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
J99734
Product name
3-Hydroxypyrazine-2-carboxylicacid
Packaging
1g
Price
$10
Updated
2021/12/16
Matrix Scientific
Product number
073680
Product name
3-Hydroxypyrazine-2-carboxylic acid
Purity
95+%
Packaging
1g
Price
$40
Updated
2021/12/16
AK Scientific
Product number
W4354
Product name
3-Hydroxypyrazine-2-carboxylicacid
Packaging
25g
Price
$81
Updated
2021/12/16
Apolloscientific
Product number
OR40047
Product name
3-Hydroxypyrazine-2-carboxylicacid
Purity
97%
Packaging
25g
Price
$83
Updated
2021/12/16
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2-HYDROXY-3-PYRAZINECARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

5424-01-1

20737-42-2

Example 4: Synthesis of 3-[3-(5-chloro-1H-benzimidazol-2-yl)-azetidin-1-yl]-pyrazine-2-carboxylic acid Step 1. Preparation of 3-hydroxypyrazine-2-carboxylic acid: 3-aminopyrazine-2-carboxylic acid (6.95 g, 0.05 mol) was dissolved in a mixed solution of water (55 mL) and sulfuric acid (55 mL, 3.75 M) and heated to 50 °C. Sodium nitrite solution (18.5 mL, 0.06 mol) was slowly added to this solution and the reaction mixture was subsequently cooled to 12 °C. During the addition, the reaction temperature was maintained in the range of 10-16 °C for 30 minutes. Afterwards, the mixture was heated to boiling over 30 minutes. After completion of the reaction, it was cooled to room temperature and filtered to collect the yellow solid. The resulting solid was dissolved in dilute sodium bicarbonate solution, acidified with 10% hydrochloric acid to precipitate the carboxylic acid product and collected by filtration. The crude product was purified by recrystallization from water to give a yellow-orange crystalline solid (4.1 g, 58% yield).

References

[1] Synthetic Communications, 2010, vol. 40, # 20, p. 2988 - 2999
[2] Patent: WO2011/143129, 2011, A1. Location in patent: Page/Page column 62
[3] Journal of Heterocyclic Chemistry, 1997, vol. 34, # 1, p. 27 - 32
[4] Patent: WO2013/169907, 2013, A1. Location in patent: Page/Page column 44; 45
[5] MedChemComm, 2015, vol. 6, # 7, p. 1311 - 1317

2-HYDROXY-3-PYRAZINECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-3-PYRAZINECARBOXYLIC ACID Suppliers

Canada 1 China 109 Germany 1 India 2 United Kingdom 6 United States 18 Global 137
ITIC MEDCHEM(SUZHOU) CO.,LTD.
Tel
0512-68323967 18015559028
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+86-512-69200360
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sales@iticmedchem.com
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China
ProdList
506
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SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
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0838-5675535
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nbcxkj@126.com
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China
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
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ShangHai DEMO Chemical Co.,Ltd
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400-021-7337 2355568890
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0086-21-50182339
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sales@demochem.com
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China
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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10186
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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11035
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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info@chemlin.com.cn
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China
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16075
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Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
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sales@heowns.com
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China
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14435
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View Lastest Price from 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-hydroxypyrazine-2-carboxylic acid 20737-42-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%+
Supply Ability
800 tons
Release date
2020-04-28
Career Henan Chemical Co
Product
2-HYDROXY-3-PYRAZINECARBOXYLIC ACID 20737-42-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-24

20737-42-2, 2-HYDROXY-3-PYRAZINECARBOXYLIC ACIDRelated Search:

3-HYDROXY-2-QUINOXALINECARBOXYLIC ACID 5-HYDROXY-2-PYRAZINECARBOXYLIC ACID 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID METHYL 6-BROMO-3-METHOXYPYRAZINE-2-CARBOXYLATE 6,7-dichloro-3-hydroxy-2-quinoxalinecarboxylic acid 3-[3-(TRIFLUOROMETHYL)PHENOXY]PYRAZINE-2-CARBOXYLIC ACID METHYL 6-CHLORO-3-METHOXYPYRAZINE-2-CARBOXYLATE 6-AMINO-3-HYDROXY-PYRIDO[2,3-B]PYRAZINE-2-CARBOXYLIC ACID METHYL 6-CHLORO-3-HYDROXYPYRAZINE-2-CARBOXYLATE METHYL 2-HYDROXY-3-PYRAZINECARBOXYLATE 3-HYDROXY-5-METHYLPYRAZINE-2-CARBOXYLIC ACID ETHYL 3-HYDROXY-5-METHYLPYRAZINE-2-CARBOXYLATE 3-METHOXYPYRAZINE-2-CARBOXYLIC ACID 5,6-DIMETHYL-3-OXO-3,4-DIHYDRO-PYRAZINE-2-CARBOXYLIC ACID 5-METHYL-3-OXO-4-PHENYL-3,4-DIHYDRO-PYRAZINE-2-CARBOXYLIC ACID 3-OXO-6-PHENYL-3,4-DIHYDROPYRAZINE-2-CARBOXYLIC ACID 7-HYDROXY-2,4-DIOXO-1,2,3,4-TETRAHYDRO-6-PTERIDINECARBOXYLIC ACID 6-CHLORO-5-METHYL-3-OXO-4-PHENYL-3,4-DIHYDRO-PYRAZINE-2-CARBOXYLIC ACID

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  • 3-Hydroxypyrazinecarboxylic acid
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  • 2-Carboxy-3-hydroxypyrazine
  • 2-oxo-1H-pyrazine-3-carboxylic acid
  • 3-hydroxy-2-piperazinecarboxylic acid
  • 3-Hydroxypyrazine-2-carboxylic acid 97%
  • 2-oxo-1H-pyrazine-3-carboxylicaci
  • 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID ISO 9001：2015 REACH
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  • pharmacetical
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