4-(TRIFLUOROMETHOXY)BENZYLAMINE

4-(TRIFLUOROMETHOXY)BENZYLAMINE Property

Boiling point:

57-60 °C10 mm Hg(lit.)

Density 

1.252 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.452(lit.)

Flash point:

172 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.75±0.10(Predicted)

form 

Liquid

Specific Gravity

1.252

color 

Clear colorless to light yellow

Sensitive 

Air Sensitive

BRN 

8200624

CAS DataBase Reference

93919-56-3(CAS DataBase Reference)

Safety

Hazard Codes 

Xi,C

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37/39

RIDADR 

UN2735

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

III

HS Code 

29222990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-(TRIFLUOROMETHOXY)BENZYLAMINE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

4-(Trifluoromethoxy)benzylamine may be used in chemical synthesis.

Synthesis

A tetrahydrofuran (30 mL) solution of 4-(trifluoromethoxy)benzyl cyanide (5.0 g, 26.72 mmol) was slowly added dropwise to a tetrahydrofuran (30 mL) solution of lithium aluminum tetrahydroxide (3.0 g, 88.44 mmol) at 0 °C. After the dropwise addition was completed, the reaction mixture was warmed to room temperature and stirred for 3 hours. Upon completion of the reaction, the mixture was cooled to 4 °C and diluted with tetrahydrofuran (50 mL). Subsequently, the reaction was quenched by sequentially adding water (3 mL), 15% sodium hydroxide solution (3 mL) and water (3 mL). After quenching, the mixture was stirred at room temperature for 15 minutes. The mixture was filtered through diatomaceous earth and the filtrate was dried with anhydrous magnesium sulfate. Finally, the filtrate was concentrated under reduced pressure to give 4-(trifluoromethoxy)benzylamine (3.1 g, 61% yield).

References

[1] Patent: WO2017/139414, 2017, A1. Location in patent: Paragraph 00215-00216