1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
- Product Name
- 1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
- CAS No.
- 301226-25-5
- Chemical Name
- 1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
- Synonyms
- 1-Oxa-5-azaspiro[2.4];5-Boc-1-oxa-5-azaspiro[2.4]heptane;tert-Butyl 1-oxa-5-azaspiro[2,4]heptane-5-carboxyate;tert-Butyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate;tert-Butyl 2-oxa-6-azaspiro[2.4]heptane-6-carboxylate;tert-butyl 1-oxa-6-azaspiro[2.4]heptane-6-carboxylate;2-oxa-6-azaspiro[2.4]heptane-6-carboxylic acid tert-butyl ester;1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester;rac-1-oxa-5-aza-spiro[2.4]heptane-5-carboxylic acid tert-butyl ester;1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester - X6275
- CBNumber
- CB3277544
- Molecular Formula
- C10H17NO3
- Formula Weight
- 199.25
- MOL File
- 301226-25-5.mol
1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Property
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- form
- liquid
- color
- Light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SYX00237
- Product name
- 1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $861
- Updated
- 2023/01/07
- Product number
- B809733
- Product name
- tert-Butyl1-Oxa-5-azaspiro[2.4]heptane-5-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H56-1-PH
- Product name
- 3-Boc-6-oxa-3-azabicyclo[3.1.0]hexane
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 4H56-1-PH
- Product name
- 3-Boc-6-oxa-3-azabicyclo[3.1.0]hexane
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
- Product number
- 070749
- Product name
- 1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester
- Purity
- 96%
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production
Uses
tert-butyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate is ureful reactant for the synthesis of spirocyclic-?3,?4-?dihydro-?2H-?benzo[b]?[1,?4]?oxazine derivatives.
Synthesis
114214-71-0
301226-25-5
At room temperature, tert-butyl 3-methylene pyrrolidine-1-carboxylate (195 mg, 1.06 mmol) was dissolved in dichloromethane (5 mL), followed by the addition of m-chloroperoxybenzoic acid (mCPBA, 275 mg, 1.60 mmol). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution (2 mL) and then the organic phase was extracted with ethyl acetate (60 mL). The organic phase was washed sequentially with water and brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting crude product was purified by fast silica gel column chromatography with the eluent being a hexane solution of 25% ethyl acetate to afford tert-butyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate (150 mg, 0.753 mmol, 71% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.91-3.42 (m, 3H), 3.48-3.16 (m, 1H), 2.93 (s, 2H), 2.35-2.17 (m, 1H), 1.93-1.79 (m, 1H), 1.47 (s, 9H).
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 21, p. 9738 - 9755
[2] Patent: WO2015/35278, 2015, A1. Location in patent: Page/Page column 89
[3] Patent: US2017/233339, 2017, A1
1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER manufacturers
- Product
- 1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 301226-25-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-07