3,4-DICHLOROISOCOUMARIN
- Product Name
- 3,4-DICHLOROISOCOUMARIN
- CAS No.
- 51050-59-0
- Chemical Name
- 3,4-DICHLOROISOCOUMARIN
- Synonyms
- 3,4-dci;3,4-DICHLOROISOCOUMARIN;3,4-dichloroisochromen-1-one;3,4-DICHLORO-2-BENZOPYRAN-1-ONE;3,4-dichloro-1H-isochroMen-1-one;1H-2-Benzopyran-1-one, 3,4-dichloro-;3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one;3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem
- CBNumber
- CB3278415
- Molecular Formula
- C9H4Cl2O2
- Formula Weight
- 215.03
- MOL File
- 51050-59-0.mol
3,4-DICHLOROISOCOUMARIN Property
- Boiling point:
- 304.7±42.0 °C(Predicted)
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMF or DMSO at a concentration of 10mM
- form
- White lyophilized solid
- color
- White to off-white
- BRN
- 6802625
Safety
- Hazard Codes
- T
- Risk Statements
- 25-36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- HazardClass
- 6.1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D7910
- Product name
- 3,4-Dichloroisocoumarin
- Purity
- serine protease inhibitor
- Packaging
- 5mg
- Price
- $247
- Updated
- 2024/03/01
- Product number
- 287815
- Product name
- 3,4-Dichloroisocoumarin
- Packaging
- 10mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- J65198
- Product name
- 3,4-Dichloroisocoumarin, 99%
- Packaging
- 10mg
- Price
- $438.65
- Updated
- 2024/03/01
- Product number
- 21194
- Product name
- 3,4-Dichloroisocoumarin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21194
- Product name
- 3,4-Dichloroisocoumarin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
3,4-DICHLOROISOCOUMARIN Chemical Properties,Usage,Production
Description
3,4-Dichloroisocoumarin (3,4-DCI) is a serine protease inhibitor. It completely inhibits enzyme activity of 24 serine proteases including human leukocyte elastase, thrombin, plasmin, Factor Xa, and Factor XIIa in vitro. 3,4-DCI stimulates caseinolytic activity of bovine pituitary multicatalytic proteinase complex (MPC) by inducing a conformational change in the MPC that exposes the caseinolytic active site. It has been used to functionally characterize the catalytic activities of multiple proteases including rat liver MPC and extracellular lipase.
Uses
Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. It is an inhibitor of Chymotrypsin and Trypsin. ,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases.
Definition
ChEBI: 3,4-dichloroisocoumarin is a member of the class of isocoumarins that is isocoumarin substituted by chloro groups at positions 3 and 4. It is a serine protease inhibitor. It has a role as a geroprotector and a serine protease inhibitor. It is a member of isocoumarins and an organochlorine compound.
General Description
A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 μM.
Biochem/physiol Actions
Product does not compete with ATP.
3,4-DICHLOROISOCOUMARIN Preparation Products And Raw materials
Raw materials
Preparation Products
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