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TN ANTIGEN

Product Name
TN ANTIGEN
CAS No.
67262-86-6
Chemical Name
TN ANTIGEN
Synonyms
TN ANTIGEN;TN EPITOPE;Ser(α-D-GalNHAc)-OH;GALNAC-ALPHA1-O-SER;GalNac-α-1-O-serine;Olanzapine Impurity 50;Galactose Impurity 9 (Tn Epitope);N-ACETYLGALACTOSAMINE, ALPHA1-O-SERINE;N-Acetyl-α-D-galactosaMinyl- 1-O-serine;N-ACETYL-ALPHA-D-GALACTOSAMINYL-1-O-SERINE
CBNumber
CB3283024
Molecular Formula
C11H20N2O8
Formula Weight
308.29
MOL File
Mol file
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TN ANTIGEN Property

Melting point:
198-201°C
Boiling point:
701.2±60.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Water
form 
Solid
pka
2.05±0.10(Predicted)
color 
Off-White to Yellow
Stability:
HYGROSCOPIC
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
53886
Product name
Tn Antigen
Purity
≥99.0% (TLC)
Packaging
1mg
Price
$404
Updated
2024/03/01
Usbiological
Product number
T2660-30
Product name
Tn Epitope
Packaging
1mg
Price
$375
Updated
2021/12/16
TRC
Product number
T020050
Product name
TnEpitope
Packaging
5mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
ATG0000871
Product name
Tn Antigen
Purity
95.00%
Packaging
1MG
Price
$673.08
Updated
2021/12/16
Biosynth Carbosynth
Product number
MA07378
Product name
2-Acetamido-2-deoxy-a-D-galactopyranosyl serine
Packaging
5mg
Price
$425
Updated
2021/12/16
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TN ANTIGEN Chemical Properties,Usage,Production

Chemical Properties

TN ANTIGEN is Yellow Solid

Uses

TN ANTIGEN is a cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines

Uses

A cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines.

Definition

ChEBI: O-(N-acetyl-alpha-D-galactosaminyl)-L-serine is a non-proteinogenic L-amino acid that is N-acetyl-alpha-D-galactosamine linked via an alpha glycosidic bond to the O at position 3 of L-serine. It has a role as a tumour antigen. It is a L-serine derivative and a non-proteinogenic L-alpha-amino acid.

General Description

Tn antigen?is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.

Biochem/physiol Actions

Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.

TN ANTIGEN Preparation Products And Raw materials

Raw materials

Preparation Products

67262-86-6, TN ANTIGENRelated Search:


  • GALNAC-ALPHA1-O-SER
  • SERINYL 2-ACETAMIDO-2-DEOXY-A-GALACTOPYRANOSIDE
  • Ser(α-D-GalNHAc)-OH
  • N-ACETYLGALACTOSAMINE, ALPHA1-O-SERINE
  • N-ACETYL-ALPHA-D-GALACTOSAMINYL-1-O-SERINE
  • TN EPITOPE
  • TN ANTIGEN
  • Serinyl 2-acetamido-2-deoxy-a-galactopyranoside, N-acetyl-a-D-galactosaminyl-1-O-serine
  • Serinyl 2-acetamido-2-deoxy-α-galactopyranoside, N-acetyl-α-D-galactosaminyl-1-O-serine
  • O-[2-(Acetylamino)-2-deoxy-alpha-D-galactopyranosyl]-L-serine
  • 2-Acetamido-2-deoxy-a-D-galactopyranosyl serine
  • N-Acetyl-α-D-galactosaMinyl- 1-O-serine
  • O-[2-(AcetylaMino)-2-deoxy-α-D-galactopyranosyl]-
  • Serinyl 2-AcetaMido-2-deoxy-α-galactopyranoside
  • GalNac-α-1-O-serine
  • O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine
  • L-Serine, O-[2-(acetylamino)-2-deoxy-α-D-galactopyranosyl]-
  • Galactose Impurity 9 (Tn Epitope)
  • (S)-3-[[(2S,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy]-2-aminopropanoic Acid
  • Olanzapine Impurity 50
  • 67262-86-6
  • C11H20N2O8
  • Carbohydrates & Derivatives
  • Amino Acids & Derivatives
  • 13C & 2H Sugars