N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE

Product Name: N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
CAS No.: 108825-65-6
Chemical Name: N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
Synonyms: C1632;Lin 28 163;Lin28 1632;Lin28-IN-1632;Lin281632, 10 mM in DMSO;Lin28-let-7 antagonist 1;Inhibitor,anxiolytic agent,Huh7 cells,inhibit,22Rv1,Lin281632;N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE;Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-
CBNumber: CB3292570
Molecular Formula: C15H15N5O
Formula Weight: 281.31
MOL File: 108825-65-6.mol

More

Less

N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Property

Melting point:: 200 °C
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
form: A crystalline solid
pka: 0.57±0.30(Predicted)
color: Off-white to light yellow

More

Less

Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 22401
Product name: Lin28 1632
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 22401
Product name: Lin28 1632
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 22401
Product name: Lin28 1632
Purity: ≥98%
Packaging: 10mg
Price: $88
Updated: 2024/03/01

Tocris

Product number: 6068
Product name: Lin281632
Purity: ≥98%(HPLC)
Packaging: 10
Price: $174
Updated: 2021/12/16

Tocris

Product number: 6068
Product name: Lin281632
Purity: ≥98%(HPLC)
Packaging: 50
Price: $749
Updated: 2021/12/16

More

Less

N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Chemical Properties,Usage,Production

Uses

Lin28 1632 is a small molecule inhibitor of Lin28.

Biological Activity

Compound 1632 (C1632) is a RNA-binding protein Lin28 inhibitor th at prevents Lin28-mediated inhibition of let-7 microRNA (miRNA) maturation by blocking Lin28 interaction with let-7 miRNA precursor (IC50 = 8 μM by ELISA using truncated pre-let-7a-2). C1632 specifically upregulates Huh7 cellular let-7a/g/f miRNA, but not RNU44 snoRNA (60 μM for 48h), inhibits the stemness and induces differentiation of mouse embryonic stem cells (mESCs, 20 μM for 48h), as well as inhibits the proliferation and stem-like properties of human cancer stem cells (CSCs) in 22Rv1 and Huh7 cultures (IC50 20-42 μM).

storage

Store at +4°C

N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Suppliers

Belgium 1 China 40 Germany 1 United Kingdom 2 United States 9 Global 53

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 993
Advantage: 64

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Suzhou Unite pharmTech Co., Ltd ,

Tel: 792-3901125 13222993784
Fax: 0512-62575043
Email: sales@unite-pharm.com
Country: China
ProdList: 321
Advantage: 56

ATK CHEMICAL COMPANY LIMITED

Tel: 021-51619050 13301662590
Fax: +86-21-51619052
Email: mandy@atkchemical.com
Country: China
ProdList: 7776
Advantage: 55

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3254
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1990
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

108825-65-6, N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDERelated Search:

N-METHYL-3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)ANILINE 3-[(3-N,N-DIMETHYLAMINO)PHENYL]-1-PROPENE N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE

N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE

Lin28 1632

Lin28-IN-1632

Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-

Lin 28 163

Lin28-let-7 antagonist 1

Inhibitor,anxiolytic agent,Huh7 cells,inhibit,22Rv1,Lin281632

C1632

Lin281632, 10 mM in DMSO

108825-65-6

C15H15N5O