N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
- Product Name
- N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
- CAS No.
- 108825-65-6
- Chemical Name
- N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
- Synonyms
- C1632;Lin 28 163;Lin28 1632;Lin28-IN-1632;Lin281632, 10 mM in DMSO;Lin28-let-7 antagonist 1;Inhibitor,anxiolytic agent,Huh7 cells,inhibit,22Rv1,Lin281632;N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE;Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-
- CBNumber
- CB3292570
- Molecular Formula
- C15H15N5O
- Formula Weight
- 281.31
- MOL File
- 108825-65-6.mol
N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Property
- Melting point:
- 200 °C
- Density
- 1.28±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:28.13(Max Conc. mg/mL);100.0(Max Conc. mM) - form
- A crystalline solid
- pka
- 0.57±0.30(Predicted)
- color
- Off-white to light yellow
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 22401
- Product name
- Lin28 1632
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 22401
- Product name
- Lin28 1632
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 22401
- Product name
- Lin28 1632
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $88
- Updated
- 2024/03/01
- Product number
- 6068
- Product name
- Lin281632
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $174
- Updated
- 2021/12/16
- Product number
- 6068
- Product name
- Lin281632
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $749
- Updated
- 2021/12/16
N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Chemical Properties,Usage,Production
Uses
Lin28 1632 is a small molecule inhibitor of Lin28.
Biological Activity
Compound 1632 (C1632) is a RNA-binding protein Lin28 inhibitor th at prevents Lin28-mediated inhibition of let-7 microRNA (miRNA) maturation by blocking Lin28 interaction with let-7 miRNA precursor (IC50 = 8 μM by ELISA using truncated pre-let-7a-2). C1632 specifically upregulates Huh7 cellular let-7a/g/f miRNA, but not RNU44 snoRNA (60 μM for 48h), inhibits the stemness and induces differentiation of mouse embryonic stem cells (mESCs, 20 μM for 48h), as well as inhibits the proliferation and stem-like properties of human cancer stem cells (CSCs) in 22Rv1 and Huh7 cultures (IC50 20-42 μM).
storage
Store at +4°C
N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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