N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE

Product Name: N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
CAS No.: 108825-65-6
Chemical Name: N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
Synonyms: C1632;Lin 28 163;Lin28 1632;Lin28-IN-1632;Lin28 inhibitor C1632;Lin281632, 10 mM in DMSO;Lin28-let-7 antagonist 1;Inhibitor,anxiolytic agent,Huh7 cells,inhibit,22Rv1,Lin281632;N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE;Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-
CBNumber: CB3292570
Molecular Formula: C15H15N5O
Formula Weight: 281.31
MOL File: 108825-65-6.mol

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N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Property

Melting point:: 200 °C
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
form: A crystalline solid
pka: 0.57±0.30(Predicted)
color: Off-white to light yellow

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3673
Product name: Lin28 inhibitor C1632
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $102
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3673
Product name: Lin28 inhibitor C1632
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $410
Updated: 2025/07/31

Cayman Chemical

Product number: 22401
Product name: Lin28 1632
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 22401
Product name: Lin28 1632
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 22401
Product name: Lin28 1632
Purity: ≥98%
Packaging: 10mg
Price: $88
Updated: 2024/03/01

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N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Chemical Properties,Usage,Production

Uses

Lin28 1632 is a small molecule inhibitor of Lin28.

Biological Activity

Compound 1632 (C1632) is a RNA-binding protein Lin28 inhibitor th at prevents Lin28-mediated inhibition of let-7 microRNA (miRNA) maturation by blocking Lin28 interaction with let-7 miRNA precursor (IC50 = 8 μM by ELISA using truncated pre-let-7a-2). C1632 specifically upregulates Huh7 cellular let-7a/g/f miRNA, but not RNU44 snoRNA (60 μM for 48h), inhibits the stemness and induces differentiation of mouse embryonic stem cells (mESCs, 20 μM for 48h), as well as inhibits the proliferation and stem-like properties of human cancer stem cells (CSCs) in 22Rv1 and Huh7 cultures (IC50 20-42 μM).

storage

Store at +4°C

N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE Suppliers

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108825-65-6, N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDERelated Search:

N-METHYL-3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)ANILINE 3-[(3-N,N-DIMETHYLAMINO)PHENYL]-1-PROPENE N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE

N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE

Lin28 1632

Lin28-IN-1632

Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]-

Lin 28 163

Lin28-let-7 antagonist 1

Inhibitor,anxiolytic agent,Huh7 cells,inhibit,22Rv1,Lin281632

C1632

Lin281632, 10 mM in DMSO

Lin28 inhibitor C1632

108825-65-6

C15H15N5O