ChemicalBook > CAS DataBase List > 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion

1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion

Product Name: 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion
CAS No.: 65996-50-1
Chemical Name: 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion
Synonyms: 1,5-dihydro-pyrrolo[3,2-a]pyri;5H-Pyrrolo[3,2-d]pyriMidine-2,4-diol;1-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione;1,5-DIHYDROPYRROLO[3,2-A]PYRIMIDINE-2,4-DION;1,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDINE-2,4-DIONE;1,5-DIHYDRO-PYRROLO[3,2-A]PYRIMIDINE-2,4-DIONE;1H,2H,3H,4H,5H-pyrrolo[3,2-d]pyriMidine-2,4-dione;1,5-Dihydro-2H-pyrrolo[3,2-d]pyrimidine-2,4(3H)-dione;1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione (7CI, 9CI, ACI)
CBNumber: CB3300013
Molecular Formula: C6H5N3O2
Formula Weight: 151.12
MOL File: 65996-50-1.mol

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1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion Property

Melting point:: >360 °C(Solv: water (7732-18-5))
Density: 1.516±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder to crystal
pka: 11.32±0.20(Predicted)
color: White to Light yellow to Light orange

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933.59.8000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: D5183
Product name: 1,5-Dihydropyrrolo[3,2-d]pyrimidine-2,4-dione
Packaging: 1G
Price: $491
Updated: 2025/07/31

TRC

Product number: D454680
Product name: 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dione
Packaging: 5g
Price: $2475
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0017414
Product name: 1,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDINE-2,4-DIONE
Purity: 95.00%
Packaging: 1G
Price: $2598.75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD22043
Product name: 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dione
Packaging: 5G
Price: $3071.3
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0017414
Product name: 1,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDINE-2,4-DIONE
Purity: 95.00%
Packaging: 5G
Price: $3349.5
Updated: 2021/12/16

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1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion Chemical Properties,Usage,Production

Uses

1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion is used for the preparation of pyrazolopyrimidine derivatives or analogs thereof as CCR4 function modulators.

Synthesis

116705-41-0

65996-50-1

General procedure for the synthesis of 1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione from (E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione: (E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione (1 g, 4.4 mmol) was dissolved in freshly prepared glacial acetic acid (50 mL) and stirred to form a slurry. Under stirring, zinc powder (stabilized, 1g per batch, 2g total) was added in two batches with an interval of 1 hour. The reaction mixture was stirred overnight and the color of the slurry was observed to change gradually from yellow to light yellow to off-white. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum to obtain a brown slurry. The product was separated from the brown slurry by ethanol precipitation to give a white solid (0.6 g, 89.8% yield). The spectral data of the product were consistent with those reported in the literature.1H NMR (400 MHz, DMSO-d6): δ 5.82-5.83 (t, 1H, J=2.28 Hz), 7.12-7.13 (t, 1H, J=2.72 Hz, J=2.96 Hz), 10.57 (s, 1H), 10.74 (s, 1H), 11.82 (s. 1H).13C NMR (400 MHz, DMSO-d6): δ 96.5, 110.9, 127.4, 135.1, 152.0, 156.3.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4354 - 4363
[2] Patent: US2016/257696, 2016, A1. Location in patent: Paragraph 0068
[3] Patent: WO2009/62258, 2009, A1. Location in patent: Page/Page column 98
[4] ChemMedChem, 2018, vol. 13, # 2, p. 178 - 185

1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion manufacturers

Career Henan Chemical Co

Product: 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion 65996-50-1
Price: US $1.00/KG
Min. Order: 1G
Purity: 99%
Supply Ability: 100KG
Release date: 2018-08-13

65996-50-1, 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dionRelated Search:

METHYL 1H-PYRROLO[3,2-B]PYRIDINE-5-CARBOXYLATE 1H-Pyrrolo[3,2-b]pyridine-3-aceticacid(8CI,9CI) 1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one(9CI) 1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid, Methyl ester 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester METHYL 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLATE 1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid 1H-Pyrrolo[3,2-c]pyridine-3-ethanamine (1H-Pyrrolo[2,3-c]pyridin-3-yl)MethanaMine methyl 1H-pyrrolo[3,2-b]pyridine-3-carboxylate 2-b]pyridin-3-aMine dihydrochloride 3-Cyano-4-azaindole Methyl 6-azaindole-3-carboxylate 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBALDEHYDE 1H-PYRAZOLO[3,4-B]PYRAZIN-3-AMINE 1,5-Dihydropyrrolo[3,2-a]pyrimidine-2,4-dion 3-[2-[4-(2-METHOXYPHENYL)PIPERAZIN-1-YL] ETHYL]PYRIMIDO[5,4-B] INDOLE-2,4-DIONE

1,5-DIHYDRO-PYRROLO[3,2-A]PYRIMIDINE-2,4-DIONE

1,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDINE-2,4-DIONE

1,5-dihydro-pyrrolo[3,2-a]pyri

1,5-DIHYDROPYRROLO[3,2-A]PYRIMIDINE-2,4-DION

1-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione

1H,2H,3H,4H,5H-pyrrolo[3,2-d]pyriMidine-2,4-dione

5H-Pyrrolo[3,2-d]pyriMidine-2,4-diol

1,5-Dihydro-2H-pyrrolo[3,2-d]pyrimidine-2,4(3H)-dione

1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione (7CI, 9CI, ACI)

65996-50-1

Heterocycle-Pyrimidine series

pyrimidine

Bases & Related Reagents

Intermediates

Nucleotides

Ketone