LDN-211904

Product Name: LDN-211904
CAS No.: 1198408-78-4
Chemical Name: LDN-211904
Synonyms: LDN-211904 Oxalate;LDN-211904 Oxalate 3-(4'-(dimethylamino)biphenyl-3-yl)-1,1-dimethylurea;N-(2-Chlorophenyl)-6-(4-piperidinyl)tmidazo[1,2-a]pyridine-3-carboxamideethanedioate;N-(2-Chlorophenyl)-6-(4-piperidinyl)tmidazo[1,2-a]pyridine-3-carboxamide ethanedioate (1:1)
CBNumber: CB33033147
Molecular Formula: C21H21ClN4O5
Formula Weight: 444.86824
MOL File: 1198408-78-4.mol

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LDN-211904 Property

storage temp.: Store at -20°C
solubility: ≤20mg/ml in DMSO;0.5mg/ml in dimethyl formamide
form: crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20453
Product name: LDN-211904
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 20453
Product name: LDN-211904
Purity: ≥98%
Packaging: 5mg
Price: $219
Updated: 2024/03/01

ApexBio Technology

Product number: C4541
Product name: LDN-211904
Packaging: 5mg
Price: $221
Updated: 2021/12/16

ApexBio Technology

Product number: C4541
Product name: LDN-211904
Packaging: 10mg
Price: $374
Updated: 2021/12/16

AK Scientific

Product number: 8636DG
Product name: Ldn-211904oxalate
Packaging: 1mg
Price: $174
Updated: 2021/12/16

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LDN-211904 Chemical Properties,Usage,Production

Biological Activity

ldn-211904 is an inhibitor of erythropoietin-producing hepatocellular carcinoma (eph) receptors.erythropoietin-producing hepatocellular carcinoma (eph) receptors, a group of highly conserved transmembrane proteins composed of multiple domains, participate in various cell signaling pathways. so far, 16 eph receptors have been identified in vertebrates, which can be divided into two major classes (epha and ephb) based on sequence similarity. mammals including humans have 14 eph receptors (epha1–epha8, epha10, ephb1–ephb4 and ephb6).

in vitro

previous study found that ldn-211904, a 4-piperidinyl analog, retained significant ephb3 inhibitory activity, and also had greater aqueous solubility due to the presence of a basic amine. ldn-211904 was profiled for functional inhibitory activity against a panel of 288 kinases and the results showed that ldn-211904 was quite selective for tyrosine kinases. the only noted exceptions were the three serine/threonine kinases p38a, p38b, and qik. in addition, only ldn-211904 showed moderate selectivity among the tyrosine kinases and little selectivity verses other epha and ephb subtypes, except for epha6 and epha7. moreover, ldn-211904 demonstrated the best stability with a t1/2 of 348 min and a clint of 4 μl/min/mg protein [1].

IC 50

79 nm for ephb3

References

[1] qiao, l. ,choi, s.,case, a., et al. structure-activity relationship study of ephb3 receptor tyrosine kinase inhibitors. bioor. med. chem. lett. 19(21), 6122-6126 (2009).

LDN-211904 Preparation Products And Raw materials

Raw materials

Preparation Products

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LDN-211904 Suppliers

China 26 United Kingdom 1 United States 4 Global 31

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
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Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
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Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
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Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

1198408-78-4, LDN-211904Related Search:

LDN-211904 Oxalate

N-(2-Chlorophenyl)-6-(4-piperidinyl)tmidazo[1,2-a]pyridine-3-carboxamide ethanedioate (1:1)

LDN-211904 Oxalate 3-(4'-(dimethylamino)biphenyl-3-yl)-1,1-dimethylurea

N-(2-Chlorophenyl)-6-(4-piperidinyl)tmidazo[1,2-a]pyridine-3-carboxamideethanedioate

1198408-78-4

C19H19ClN4OC2H2O4

C2H2O4C19H19ClN4O