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Syk Inhibitor II

Product Name
Syk Inhibitor II
CAS No.
227449-73-2
Chemical Name
Syk Inhibitor II
Synonyms
Syk Inhibitor II;Syk Inhibitor II (hydrochloride);Syk Inhibitor II dihydrochloride;Syk Inhibitor II dihydrochloride, 10 mM in DMSO;2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride
CBNumber
CB33036911
Molecular Formula
C14H16ClF3N6O
Formula Weight
376.77
MOL File
227449-73-2.mol
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Syk Inhibitor II Property

storage temp. 
Store at -20°C
solubility 
DMF: 2 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.3 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
color 
off-white
InChI
1S/C14H15F3N6O.2ClH.2H2O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18;;;;/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23);2*1H;2*1H2
InChIKey
LCACSMNPIITJGG-UHFFFAOYSA-N
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Safety

WGK Germany 
WGK 1
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
574712
Product name
Syk Inhibitor II - CAS 227449-73-2 - Calbiochem
Packaging
1mg
Price
$404
Updated
2023/01/07
Cayman Chemical
Product number
18805
Product name
Syk Inhibitor II (hydrochloride)
Purity
≥98%
Packaging
500μg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
18805
Product name
Syk Inhibitor II (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$228
Updated
2024/03/01
Cayman Chemical
Product number
18805
Product name
Syk Inhibitor II (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$952
Updated
2024/03/01
TRC
Product number
S900000
Product name
2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamideHydrochloride
Packaging
0.5mg
Price
$125
Updated
2021/12/16
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Syk Inhibitor II Chemical Properties,Usage,Production

Uses

2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride was identified via a small molecule screening assay. In addition, this compound inhibits tyrosine kinase and may be a useful reagent to investigate cellular signalling pathways.

Biological Activity

Cell permeable: yes', 'Primary Target
Syk', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 41 nM against Syk; 460 nM against FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro

in vivo

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg[1].

Animal Model:ICR mice[1]
Dosage:10, 30, 100 mg/kg
Administration:S.c.; 30 min before antigen challenge
Result:Inhibited the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg.

IC 50

5-HT Receptor: 460 nM (IC50)

Syk Inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

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Syk Inhibitor II Suppliers

CHINA 34 United States 4 Global 38
BOC Sciences
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16314854226
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info@bocsci.com
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United States
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Angel Pharmatech, Ltd.
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17317130613
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QQ3358272972
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3358272972@qq.com
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China
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Shanghai Hongye Biotechnology Co. Ltd
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400-9205774
Email
sales@glpbio.cn
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China
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6777
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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order@med-bio.cn
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Energy Chemical
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TargetMol Chemicals Inc.
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marketing@tsbiochem.com
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227449-73-2, Syk Inhibitor IIRelated Search:


  • Syk Inhibitor II
  • Syk Inhibitor II (hydrochloride)
  • 2-[(2-Aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide Hydrochloride
  • Syk Inhibitor II dihydrochloride
  • Syk Inhibitor II dihydrochloride, 10 mM in DMSO
  • 227449-73-2