CNQX disodium salt
- Product Name
- CNQX disodium salt
- CAS No.
- 479347-85-8
- Chemical Name
- CNQX disodium salt
- Synonyms
- 3-dione disodium;6-Cyano-7-nitroquinoxaline-2;CNQX disodium salt, AMPA / kainate antagonist;CNQX disodium salt (mM/ml), AMPA / kainate antagonist (water soluble);7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, disodium salt
- CBNumber
- CB33037190
- Molecular Formula
- C9H5N4NaO4
- Formula Weight
- 256.15
- MOL File
- 479347-85-8.mol
CNQX disodium salt Property
- storage temp.
- Desiccate at RT
- solubility
- ≥27.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- form
- solid
- color
- Brown or yellow
- Water Solubility
- Soluble to 20 mM in water
N-Bromosuccinimide Price
- Product number
- C600003
- Product name
- CNQXDisodiumSalt
- Packaging
- 100mg
- Price
- $1210
- Updated
- 2021/12/16
- Product number
- B6567
- Product name
- CNQXdisodiumsalt
- Packaging
- 10mg
- Price
- $74
- Updated
- 2021/12/16
- Product number
- B6567
- Product name
- CNQXdisodiumsalt
- Packaging
- 50mg
- Price
- $209
- Updated
- 2021/12/16
- Product number
- DC10671
- Product name
- CNQXdisodiumsalt
- Purity
- >98%
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- DC10671
- Product name
- CNQXdisodiumsalt
- Purity
- >98%
- Packaging
- 250mg
- Price
- $550
- Updated
- 2021/12/16
CNQX disodium salt Chemical Properties,Usage,Production
Uses
CNQX Disodium Salt (cas# 479347-85-8) is a useful research chemical.CNQX Disodium Salt was used in the study of compositions and methods for treating neurological disorders or damage.
Biological Activity
cnqx disodium salt is an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) and kainate receptors, with ic50 values of 0.3 and 1.5 μm, respectively [1].ampa and kainate receptors, collectively referred to as non-n-methyl-d-aspartate receptors, are distinct receptor complexes, but activated by the same agonists. ampa and kainate receptors are involved in rapidly desensitizing responses in central nervous system [2].in thalamic reticular nucleus neurons, cnqx (20 μm) depolarized all cells tested in a similar manner as dnqx. with longer cnqx application (5 min vs. 1 min), the depolarization persisted throughout cnqx application. however, in ventrobasal neurons, cnqx (20 μm) produced negligible effects on the membrane potential [3].in sprague-dawley rats, pretreatment with cnqx (0.02, 0.1, 0.6, 3 and 15 mg/kg), administered intraperitoneally 15 min before capsaicin, significantly reduced c-fos-labelled cells within trigeminal nucleus caudalis by a maximum of 45%. the number of c-fos-like immunoreactivity cells within lateral reticular, medullary reticular, and solitary tract nuclei was not affected [4].[1]. honoré t, davies s n, drejer j, et al. quinoxalinediones: potent competitive non-nmda glutamate receptor antagonists. science, 1988, 241(4866): 701-703.[2]. bettler b, mulle c. ampa and kainate receptors. neuropharmacology, 1995, 34(2): 123-139.[3]. lee s h, govindaiah g, cox c l. selective excitatory actions of dnqx and cnqx in rat thalamic neurons. journal of neurophysiology, 2010, 103(4): 1728-1734.[4]. mitsikostas d d, sanchez del rio m, waeber c, et al. non-nmda glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis. british journal of pharmacology, 1999, 127(3): 623-630.
storage
Room temperature (desiccate)
CNQX disodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
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