SR 59230A HCl

Product Name: SR 59230A HCl
CAS No.: 1135278-41-9
Chemical Name: SR 59230A HCl
Synonyms: SR-59230A hydrochloride,SR59230A hydrochloride;SR 59230A hydrochloride, beta3 adrenoceptor antagonist
CBNumber: CB33038511
Molecular Formula: C21H27NO2.HCl
Formula Weight: 361.91
MOL File: 1135278-41-9.mol

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SR 59230A HCl Property

storage temp.: Store at 4°C
solubility: Soluble in DMSO
form: solid
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21407
Product name: SR 59230A (hydrochloride)
Purity: ≥99%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 21407
Product name: SR 59230A (hydrochloride)
Purity: ≥99%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 21407
Product name: SR 59230A (hydrochloride)
Purity: ≥99%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 21407
Product name: SR 59230A (hydrochloride)
Purity: ≥99%
Packaging: 25mg
Price: $442
Updated: 2024/03/01

TRC

Product number: S684443
Product name: SR59230AHydrochloride
Packaging: 10mg
Price: $145
Updated: 2021/12/16

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SR 59230A HCl Chemical Properties,Usage,Production

Description

SR 59230A (hydrochloride) is a β₃-adrenergic receptor (β₃-AR) antagonist (pA₂s = 8.76, 7.31, and 6.63 in rat proximal colon, guinea pig atrium, and guinea pig trachea, respectively). It is less selective for β₃-AR in cells transfected with the human β-AR subtypes (K_is = 16.4, 61.9, and 122 nM for β₁-, β₂-, and β₃-AR, respectively). At low concentrations, SR 59230A blocks MDMA-induced hyperthermia, while at high concentrations it blocks hyperthermia but also increases heat loss through an α₁-AR antagonistic mechanism. In adipocytes, it induces phosphorylation of p38 MAPK via the G_s pathway. It has also been used in studies of heart failure to elucidate the role of the β₃-ARs.

Uses

SR 59230A Hydrochloride is a potent and selective β3 adrenergic receptor antagonist.

in vivo

MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. ? SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA^[4].

Animal Model:	Male C-57BL6J wild-type mice (22-35 g)^[4]
Dosage:	0.5 or 5 mg/kg
Administration:	Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg).
Result:	Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.

IC 50

β adrenergic receptor

storage

Store at RT

References

[1] L MANARA. Functional identification of rat atypical beta-adrenoceptors by the first beta 3-selective antagonists, aryloxypropanolaminotetralins.[J]. British Journal of Pharmacology, 1996, 117 3: 435-442. DOI: 10.1111/j.1476-5381.1996.tb15209.x
[2] C HOFFMANN. Comparative pharmacology of human beta-adrenergic receptor subtypes–characterization of stably transfected receptors in CHO cells.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 2004, 369 2: 151-159. DOI: 10.1007/s00210-003-0860-y
[3] SOTIRIA BEXIS James R D. Role of α1- and β3-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse[J]. British Journal of Pharmacology, 2009, 158 1: 259-266. DOI: 10.1111/j.1476-5381.2009.00186.x
[4] K. MIZUNO. Stimulation of β3‐adrenoceptors causes phosphorylation of p38 mitogen‐activated protein kinase via a stimulatory G protein‐dependent pathway in 3T3‐L1 adipocytes[J]. British Journal of Pharmacology, 2002, 135 1. DOI: 10.1038/sj.bjp.0704537
[5] RUN-TAO GAN. Chronic blocking of β3-adrenoceptor ameliorates cardiac function in rat model of heart failure[J]. Chinese Medical Journal, 2007, 120 1: 2250-2255. DOI: 10.1097/00029330-200712020-00018

SR 59230A HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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SR 59230A HCl Suppliers

China 24 United Kingdom 1 United States 8 USA 1 Global 34

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SR-59230A hydrochloride,SR59230A hydrochloride

SR 59230A hydrochloride, beta3 adrenoceptor antagonist

1135278-41-9