ChemicalBook > CAS DataBase List > 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one

Product Name
1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one
CAS No.
1332454-07-5
Chemical Name
1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one
Synonyms
PK-THPP;PKTHPP,PK THPP;PK-THPP >=98% (HPLC);1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one;1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone;1-Butanone, 1-[1-[6-([1,1'-biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-
CBNumber
CB33039851
Molecular Formula
C29H32N4O2
Formula Weight
468.59
MOL File
1332454-07-5.mol
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1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one Property

storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
powder
color 
white to beige
Water Solubility 
H2O: 10mg/mL, clear
DMSO: 2mg/mL, clear (warmed)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1326
Product name
PK-THPP
Purity
≥98% (HPLC)
Packaging
5MG
Price
$150
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1326
Product name
PK-THPP
Purity
≥98% (HPLC)
Packaging
25MG
Price
$594
Updated
2025/07/31
Cayman Chemical
Product number
29473
Product name
PK-THPP
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
29473
Product name
PK-THPP
Packaging
25mg
Price
$493
Updated
2024/03/01
Cayman Chemical
Product number
29473
Product name
PK-THPP
Packaging
1mg
Price
$45
Updated
2024/03/01
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1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one Chemical Properties,Usage,Production

Uses

PK-THPP is a potent TWIK-related acid-sensitive K(+) ion channel (TASK-3 ion channel) blocker (IC50s are 35 nM and 300 nM for TASK-3 and TASK-1, respectively)[1]. PK-THPP increases breathing rate and induces respiratory alkalosis in rats[2].

Biochem/physiol Actions

PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP was found to act as a respiratory stimulant, stimulating breathing in isoflurane-anesthetized rats.

storage

Store at +4°C

References

[1] Coburn CA,et al. Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem. 2012 Jan 2;7(1):123-33. DOI:10.1002/cmdc.201100351
[2] Cotten JF. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth Analg. 2013 Apr;116(4):810-6. DOI:10.1213/ANE.0b013e318284469d

1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one Suppliers

China 23 United Kingdom 1 United States 4 USA 1 Global 29
TargetMol Chemicals Inc.
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United States
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Aladdin Scientific
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tp@aladdinsci.com
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United States
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52923
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Cayman Chemical Company
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cayman@caymanchem.com
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United States Biological
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1332454-07-5, 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-oneRelated Search:


  • 1-{1-[6-(biphenyl-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]piperidin-4-yl}butan-1-one
  • 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
  • PK-THPP
  • 1-Butanone, 1-[1-[6-([1,1'-biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-
  • PK-THPP >=98% (HPLC)
  • PKTHPP,PK THPP
  • 1332454-07-5